Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study

BMC Nephrology

Research Article

Hyung-Jin Yoon¹  Rina So¹  Minseon Park²  Kwon Wook Joo³ 

[1] Department of Biomedical Engineering, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Republic of Korea;Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;

关键词: Chronic kidney disease;    Glomerular filtration rate;    Metabolic acidosis;    Renal hyperfiltration;    Serum bicarbonate;   

DOI  :  10.1186/s12882-015-0218-y

 received in 2015-04-22, accepted in 2015-12-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundLower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF.MethodsThe health data of 41,886 adults with an estimated glomerular filtration rate (eGFR) ≥60 mL/min per 1.73 m2 were analyzed. The eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation and RHF was defined as eGFR with adjusted residuals > sex-specific 95th percentile.ResultsThe adjusted mean of eGFR was lower in the highest quintile of serum bicarbonate than in other quintiles, after adjusting for confounders. A lower percentile rank of serum bicarbonate was associated with higher odds of RHF. The odds ratio (OR) for RHF in the lowest quintile of serum bicarbonate was 1.39 (95 % confidence interval, 95 % CI, 1.11–1.75) compared to the highest, after adjusting for confounders. With subgroup analysis, the association was prominent in participants with a body mass index >25 kg/m2 (OR 1.98, 95 % CI 1.32–2.95 in the lowest quintile compared to the highest), compared to those with a body mass index ≤25 kg/m2 (OR 1.18, 95 % CI 0.89–1.56 in the lowest quintile compared to the highest).ConclusionsThis study observed an association between lower serum bicarbonate and higher odds of RHF and the possible differential effect of obesity in this association. It is necessary to confirm the association between lower serum bicarbonate and RHF and its causality.

【 授权许可】

CC BY   
© Park et al. 2016