Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk

BMC Cancer

Research Article

Fulvio Ricceri¹  Maria Teresa Giraudo²  Dario Milanese²  Laura Fiorini³  Carlotta Sacerdote³  Francesca Fasanelli³  Veronica Sciannameo⁴ 

[1] Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole, 10, Orbassano(TO), Italy;Unit of Epidemiology, Regional Health Service ASL TO3, Via Sabaudia, 164, Grugliasco(TO), Italy;Department of Mathematics “Giuseppe Peano”, University of Turin, Via Carlo Alberto, 10, Turin, Italy;Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Via Santena 7, Turin, Italy;Unit of Epidemiology, Regional Health Service ASL TO3, Via Sabaudia, 164, Grugliasco(TO), Italy;

关键词: Endometrial cancer;    Fruits and vegetables;    Mediterranean diet;    Dietary inflammatory index;    Case-control study;   

DOI  :  10.1186/s12885-017-3754-y

 received in 2016-11-29, accepted in 2017-11-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEndometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation.MethodsIn the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy. Using logistic regression, we investigated the role of fruit and vegetable intake, adherence to the Mediterranean diet (MD), and the dietary inflammatory index (DII) in endometrial cancer risk.ResultsWomen in the highest quintile of vegetable intake had a statistically significantly lower endometrial cancer risk (adjusted OR 5th quintile vs 1st quintile: 0.34, 95% CI 0.17-0.68). Women with high adherence to the MD had a risk of endometrial cancer that was about half that of women with low adherence to the MD (adjusted OR: 0.51, 95% CI 0.39-0.86). A protective effect was detected for all the lower quintiles of DII, with the highest protective effect seen for the lowest quintile (adjusted OR 5th quintile vs 1st quintile: 3.28, 95% CI 1.30-8.26).ConclusionsThese results suggest that high vegetable intake, adherence to the MD, and a low DII are related to a lower endometrial cancer risk, with several putative connected biological mechanisms that strengthen the biological plausibility of this association.

【 授权许可】

CC BY   
© The Author(s). 2017