Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population

BMC Cancer

Research Article

Jun Huang¹  Huifen Jiang²  Xinhua Zhu³  Yuehui Liu³  Mang Xiao⁴  Lei Zhang⁴  Sunhong Hu⁴ 

[1] Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Key Laboratory of Biotherapy of Zhejiang province, Zhejiang University, Hangzhou, China;Department of Clinical Laboratory, Zhejiang cancer hospital, Hangzhou, China;Department of Otolaryngology-Head and Neck Surgery, The second affected hospital to Nanchang University, Nanchang, China;Department of Otorhinolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Biotherapy of Zhejiang province, Zhejiang University, Hangzhou, China;

关键词: Genotype Carrier;    MDM2 SNP309;    MDM2 Expression;    TP53 Arg72Pro;    TP53 Polymorphism;   

DOI  :  10.1186/1471-2407-10-147

 received in 2009-10-26, accepted in 2010-04-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of common cancers. However, the relationship between these two functional polymorphisms and nasopharyngeal carcinoma (NPC) susceptibility has not been explored.MethodsIn this study, we performed a case-control study between 522 NPC patients and 722 healthy controls in a Chinese population by using PCR-RFLP.ResultsWe found an increased NPC risk associated with the MDM2 GG (odds ratio [OR] = 2.83, 95% confidence interval [CI] = 2.08-3.96) and TG (OR = 1.49, 95% CI = 1.16-2.06) genotypes. An increased risk was also associated with the TP53 Pro/Pro genotype (OR = 2.22, 95% CI = 1.58-3.10) compared to the Arg/Arg genotype. The gene-gene interaction of MDM2 and TP53 polymorphisms increased adult NPC risk in a more than multiplicative manner (OR for the presence of both MDM2 GG and TP53 Pro/Pro genotypes = 7.75, 95% CI = 3.53-17.58).ConclusionThe findings suggest that polymorphisms of MDM2 and TP53 genes may be genetic modifier for developing NPC.

【 授权许可】

Unknown   
© Xiao et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.