Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients

Cardiovascular Diabetology

Original Investigation

Ruiyan Zhang¹  Qi Zhang¹  Lin Lu²  Weifeng Shen²  Wei Wang²  Lingjie Wang²  Xianling Zhang³  Wenhui Peng³  Qiujing Chen³ 

[1] Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, People's Republic of China;Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, People's Republic of China;Institute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, People's Republic of China;Institute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, People's Republic of China;

关键词: Coronary Artery Disease;    Chromosome 9p21;    Rs1333049 Polymorphism;    Genotype Carrier;    Plaque Progression;   

DOI  :  10.1186/1475-2840-9-33

 received in 2010-07-02, accepted in 2010-08-06,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWe sought to explore the association of variant rs1333049 on chromosome 9p21.3 with coronary artery disease (CAD) and angiographic plaque progression in non-diabetic and type 2 diabetic patients.MethodsGenotyping and quantitative coronary angiography (QCA) were performed in 2046 Chinese Han patients (1012 diabetic cases) undergoing coronary angiography; 430 of them received repeat angiographic studies at 1-year follow-up.ResultsCC genotype at rs1333049 on chromosome 9p21.3 was associated with CAD (unadjusted OR 1.524, p = 0.001 and adjusted OR 1.859, p = 0.005, respectively). However, CC genotype had no magnified association with CAD in diabetic patients (OR 1.275, p = 0.150) compared with non-diabetic counterparts (OR 1.446, p = 0.020) after adjusting for conventional risk factors. During angiographic follow-up, non-diabetic patients (n = 280) had significant decrease in minimal lumen diameter and increase in percent diameter stenosis among the three genotypes (p = 0.005 and p = 0.038, respectively), demonstrating that CC or GC genotype carriers had a more severe plaque progression than GG genotype carriers. In patients with type 2 diabetes (n = 150), although plaque progression was more severe than that in non-diabetic counterparts, no relations existed between plaque progression and genotypes. Rs1333049 was an independent determinant of plaque progression for non-diabetic (OR 3.468, p = 0.004 and OR 4.339, p = 0.002 for GC and CC genotype, respectively) but not for diabetic patients (OR 0.529, p = 0.077 and 0R 0.878, p = 0.644 for GC and CC genotype, respectively).ConclusionsThis study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population. Rs1333049 polymorphism is an independent determinant for coronary plaque progression in non-diabetic but not in type 2 diabetic patients.

【 授权许可】

Unknown   
© Wang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.