The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study

BMC Genomics

Research Article

Dan Wu¹  Yaodong Hu¹  Lei Zhang¹  Yanfa Sun²  Guiping Zhao³  Ranran Liu³  Peng Li³  Maiqing Zheng³  Jie Wen⁴ 

[1] Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193, Beijing, P.R. China;Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193, Beijing, P.R. China;College of Animal Science and Technology, Yangzhou University, 225009, YangzhouJiangsu, P.R. China;Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193, Beijing, P.R. China;State Key Laboratory of Animal Nutrition, 100193, Beijing, P.R. China;Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193, Beijing, P.R. China;State Key Laboratory of Animal Nutrition, 100193, Beijing, P.R. China;College of Animal Science and Technology, Yangzhou University, 225009, YangzhouJiangsu, P.R. China;

关键词: Chicken;    GWAS;    Meat quality traits;    Abdominal fat;    Candidate genes;   

DOI  :  10.1186/1471-2164-14-458

 received in 2013-01-30, accepted in 2013-05-28,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundMeat quality is an important economic trait in chickens. To identify loci and genes associated with meat quality traits, we conducted a genome-wide association study (GWAS) of F2 populations derived from a local Chinese breed (Beijing-You chickens) and a commercial fast-growing broiler line (Cobb-Vantress).ResultsIn the present study, 33 association signals were detected from the compressed mixed linear model (MLM) for 10 meat quality traits: dry matter in breast muscle (DMBr), dry matter in thigh muscle (DMTh), intramuscular fat content in breast muscle (IMFBr), meat color lightness (L*) and yellowness (b*) values, skin color L*, a* (redness) and b* values, abdominal fat weight (AbFW) and AbFW as a percentage of eviscerated weight (AbFP). Relative expressions of candidate genes identified near significant signals were compared using samples of chickens with High and Low phenotypic values. A total of 14 genes associated with IMFBr, meat color L*, AbFW, and AbFP, were differentially expressed between the High and Low phenotypic groups. These genes are, therefore, prospective candidate genes for meat quality traits: protein tyrosine kinase (TYRO3) and microsomal glutathione S-transferase 1 (MGST1) for IMFBr; collagen, type I, alpha 2 (COL1A2) for meat color L*; and RET proto-oncogene (RET), natriuretic peptide B (NPPB) and sterol regulatory element binding transcription factor 1 (SREBF1) for the abdominal fat (AbF) traits.ConclusionsBased on the association signals and differential expression of nearby genes, 14 candidate loci and genes for IMFBr, meat L* and b* values, and AbF are identified. The results provide new insight into the molecular mechanisms underlying meat quality traits in chickens.

【 授权许可】

Unknown   
© Sun et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.