Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

BMC Cancer

Research Article

Li-Xu Yan¹  Pei-Lin Zhuang²  Dan Xie³  Mu-Yan Cai³  Zi-Ying Lin³  Yun Cao³  Zhen-Xing Liang³  Jie-Wei Chen³  Jing-Ping Yun³ 

[1] Department of Pathology and Laboratory Medicine, Guangdong General Hospital, Guangzhou, China;Department of Prosthodontics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China;Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Department of Pathology, Sun Yat-sen University Cancer Center, No. 651, Dongfeng Road East, 510060, Guangzhou, China;

关键词: C-reactive protein;    Intrahepatic cholangiocarcinoma;    Prognosis;   

DOI  :  10.1186/s12885-016-2827-7

 received in 2015-12-06, accepted in 2016-09-30,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSerum C-reactive protein (CRP), an acute inflammatory response biomarker, has been recognized as an indicator of malignant disease progression. However, the prognostic significance of CRP levels collected before tumor removal in intrahepatic cholangiocarcinoma requires further investigation.MethodsWe sampled the CRP levels in 140 patients with intrahepatic cholangiocarcinoma who underwent hepatectomies with regional lymphadenectomies between 2006 and 2013. A retrospective analysis of the clinicopathological data was performed. We focused on the impact of serum CRP on the patients’ cancer-specific survival and recurrence-free survival rates.ResultsHigh levels of preoperative serum CRP were significantly associated with well-established clinicopathologic features, including gender, advanced tumor stage, and elevated carcinoembryonic antigen and carbohydrate antigen 19-9 levels (P < 0.05). Univariate analysis demonstrated a significant association between high levels of serum CRP and adverse cancer-specific survival (P = 0.001) and recurrence-free survival (P < 0.001). In patients with stage I/II intrahepatic cholangiocarcinoma, the serum CRP level was a prognostic indicator for cancer-specific survival. In patients with stage I/II or stage III/IV, the serum CRP level was a prognostic indicator for recurrence-free survival (P < 0.05). Additionally, multivariate analysis identified serum CRP level in intrahepatic cholangiocarcinoma as an independent prognostic factor (P < 0.05).ConclusionsWe confirmed a significant association of elevated pre-operative CRP levels with poor clinical outcomes for the tested patients with intrahepatic cholangiocarcinoma. Our results indicate that the serum CRP level may represent a useful factor for patient stratification in intrahepatic cholangiocarcinoma management.

【 授权许可】

CC BY   
© The Author(s). 2016