Fibrinogen/albumin ratio index is an independent predictor of recurrence-free survival in patients with intrahepatic cholangiocarcinoma following surgical resection

World Journal of Surgical Oncology

Hong Wu¹  Guoteng Qiu¹  Hu Liu¹  Fengjuan Hu² 

[1] Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, 610041, Chengdu, China;Laboratory of Liver Surgery, West China Hospital, Sichuan University, 610041, Chengdu, China;The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 610041, Chengdu, China;

关键词: Intrahepatic cholangiocarcinoma;    Fibrinogen;    Albumin;    Fibrinogen-to-albumin ratio;    Prognosis;    Surgery;   

DOI  :  10.1186/s12957-021-02330-2

来源: Springer

【 摘 要 】

BackgroundSystemic inflammation and nutritional status are associated with tumor development and progression. This study investigated the prognostic value of fibrinogen/albumin ratio index (FARI) in predicting recurrence-free survival (RFS) in patients with intrahepatic cholangiocarcinoma (ICC) undergoing hepatectomy.MethodsA retrospective cohort was conducted including patients who received curative hepatectomy for ICC at our hospital between May 2010 and December 2016. We collected the preoperative hematologic parameters and clinical data of all patients. Time-dependent receiver operating characteristic curve was used to identify the optimal cutoff value of FARI. The association between FARI-high and FARI-low group was investigated by using the Kaplan–Meier method. A nomogram based on the results of univariate and multivariate analysis was established.ResultsA total of 394 patients with ICC who underwent hepatectomy at our hospital were enrolled. K-M analysis revealed that increased FARI was related to reduced RFS (P < 0.001). The multivariate analysis indicated that tumor number, tumor–node–metastasis stage, lymph node metastasis, cirrhosis, serum carbohydrate antigen 19-9, and FARI were independent predictors of RFS, and the ROC curve analysis showed that the optimal cutoff value for FARI was 0.084 based on the Youden index. The nomogram for FARI showed satisfactory accuracy in predicting RFS for ICC patients undergoing hepatectomy (C index = 0.663; AIC = 3081.07).ConclusionPreoperative FARI is an independent predictor of RFS in patients undergoing hepatectomy for ICC, and the nomogram can be useful for clinical decision-making in the postoperative management of these patients.

【 授权许可】

CC BY