Predictor parameters for poor prognosis in patients with sudden sensorineural hearing loss: fibrinogen to albumin ratio vs C-reactive protein to albumin ratio

Revista Brasileira de Otorrinolaringologia

article

Serkan Cayir¹  Serkan Kayabasi²  Omer Hizli³ 

[1] Aksaray University, Aksaray Education and Research Hospital, Department of ENT;Aksaray University, Faculty of Medicine, Department of ENT;Giresun University, Prof Dr. A. Ilhan Ozdemir Education and Research Hospital, Department of ENT

关键词: Sudden sensorineural hearing loss;    Fibrinogen;    C-reactive protein;    Albumin;   

DOI  :  10.1016/j.bjorl.2020.06.010

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: Prognosis of sudden sensorineural hearing loss may be predicted using several parameters of laboratory blood analysis. Objective: To identify and investigate the most significant indicator parameters related to the poor prognosis of sudden sensorineural hearing loss. Methods: Eighty-eight patients were included, and three groups were constituted: non-recovery group with14 patients, recovery group with 33 patients and control group with 41 individuals. We compared fibrinogen-to-albumin ratio, C-reactive protein-to-albumin ratio, neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, white blood cell and hemoglobin of the groups. Then, we investigated the most significant indicator parameters related to the poor prognosis of sudden hearing loss. Results: The mean hemoglobin, mean platelet-lymphocyte ratio and median white blood cell values did not significantly differ among three groups (p = 0.36, p = 0.86 and p = 0.79, respectively). A significant difference of median fibrinogen-albumin ratio, C-reactive protein-albumin ratio, neutrophil-to-lymphocyte ratio was evident among three groups (p < 0.001, p = 0.003 and p = 0.002, respectively). Median fibrinogen-albumin ratio, C-reactive protein-albumin ratio and neutrophil-to-lymphocyte ratio values were significantly greater in the non-recovery group, compared with the controls (p < 0.001, p = 0.003 and p = 0.005, respectively). Median fibrinogento-albumin ratio, C-reactive protein-to-albumin ratio and neutrophil-to-lymphocyte ratio were significantly greater in the recovery group, compared with the controls (p < 0.001, p = 0.013 and p = 0.005, respectively). Moreover, the median fibrinogen-albumin ratio was significantly greater in the non-recovery group compared with the recovery group (p = 0.017). However, no statistically significant difference of median C-reactive protein-albumin ratio, neutrophil-tolymphocyte was evident between the non-recovery and recovery groups (p = 0.15). Conclusion: Increased levels of fibrinogen-albumin ratio may be predictive for poor prognosis in patients with sudden sensorineural hearing loss.

【 授权许可】

CC BY