Ocular perfusion pressure and ophthalmic artery flow in patients with normal tension glaucoma

BMC Ophthalmology

Research Article

May May Choo¹  Nadine Isaacs¹  Amir Samsudin¹  Zahari Mimiwati¹  Norlina Ramli¹  Mei-Ling Sharon Tai² 

[1] Department of Ophthalmology, University of Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia;Division of Neurology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

关键词: Glaucoma;    Resistive Index;    Visual Field Defect;    Peak Systolic Velocity;    Ophthalmic Artery;   

DOI  :  10.1186/s12886-016-0215-3

 received in 2015-11-01, accepted in 2016-04-12,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundVascular insufficiency has been reported to be a cause of normal tension glaucoma (NTG). The aim of this study was to compare ocular perfusion pressure (OPP) and ophthalmic artery flow (OAF) between patients with NTG and those without glaucoma.MethodsWe considered one eye each from 31 NTG and 15 non-glaucoma control patients. Blood pressure and intraocular pressure (IOP) were measured in the sitting position, for calculation of OPP. Humphrey visual field (HVF) assessment was then carried out on NTG patients. All patients then underwent Transcranial Doppler ultrasound measurements of OAF parameters, including mean flow velocity (MFV), end diastolic velocity (EDV), peak systolic velocity (PSV) and resistive index (RI). We looked at differences in OPP and OAF parameters between the two groups, and their correlations in NTG patients. T-tests, χ2, ANOVA and Pearson Correlation tests were performed, with p < 0.05 considered statistically significant.ResultsThere were no statistically significant differences in OPP between the NTG and control groups (60.5+/-8.7 mmHg and 62.9+/-10.2 mmHg respectively, p = 0.393), and also no statistically significant differences in MFV, EDV, PSV and RI (all p > 0.05). In the NTG group, there were positive correlations between OPP and both MFV (r = 0.416, p = 0.020) and EDV (r = 0.369, p = 0.041). There were no statistically significant correlations between HVF mean deviation and OPP or OAF parameters (all p > 0.05).ConclusionThere is no difference in OPP and OAF parameters between patients with NTG and non-glaucoma controls, suggesting that vascular insufficiency or dysregulation by themselves may not account for the pathogenesis of NTG.

【 授权许可】

CC BY   
© Samsudin et al. 2016