Vitamin D deficiency and supplementation in pregnancy in a multiethnic population-based cohort

BMC Pregnancy and Childbirth

Research Article

Line Sletner¹  Kåre I. Birkeland²  Anne K. Jenum³  Per Lagerløv³  Kirsten V. Knutsen³  Åse R. Eggemoen³  Ragnhild S. Falk⁴ 

[1] Department of Child and Adolescence Medicine, Akershus University Hospital, Lørenskog, Norway;Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;Department of General Practice, Institute of Health and Society, University of Oslo, Postboks 1130 Blindern, N-0318, Oslo, Norway;Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway;

关键词: Vitamin D;    Deficiency;    Supplementation;    Pregnancy;    Ethnic minority;   

DOI  :  10.1186/s12884-016-0796-0

 received in 2015-06-29, accepted in 2016-01-05,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTo investigate ethnic differences in vitamin D levels during pregnancy, assess risk factors for vitamin D deficiency and explore the effect of vitamin D supplementation in women with deficiency in early pregnancy.MethodsThis is a population-based, multiethnic cohort study of pregnant women attending Child Health Clinics for antenatal care in Oslo, Norway. Serum-25-hydroxyvitamin D [25(OH)D] was measured in 748 pregnant women (59 % ethnic minorities) at gestational weeks (GW) 15 (SD:3.6) and 28 (1.4). Women with 25(OH)D <37 nmol/L at GW 15 were for ethical reasons recommended vitamin D3 supplementation. Main outcome measure was 25(OH)D, and linear regression models were performed.ResultsSevere deficiency (25(OH)D <25 nmol/L) was found at GW 15 in 45 % of women from South Asia, 40 % from the Middle East and 26 % from Sub-Saharan Africa, compared to 2.5 % in women from East Asia and 1.3 % of women from Western Europe. Women from South Asia, the Middle East and Sub-Saharan Africa had mean values that were −28 (95 % CI:-33, −23), −24 (−29, −18) and −20 (−27, −13) nmol/L lower than in Western women, respectively. Ethnicity, education, season and intake of vitamin D were independently associated with 25(OH)D. At GW 28, the mean 25(OH)D had increased from 23 (SD:7.8) to 47 (27) nmol/L (p < 0.01) in women who were recommended vitamin D supplementation, with small or no change in women with sufficient vitamin D levels at baseline.ConclusionsVitamin D deficiency was prevalent among South Asian, Middle Eastern and African women. The serum levels of 25(OH)D increased significantly from GW 15 to 28 in vitamin D deficient women who received a recommendation for supplementation. This recommendation of vitamin D supplementation increased vitamin D levels in deficient women.

【 授权许可】

CC BY   
© Eggemoen et al. 2016