Sleep characteristics in child and adolescent offspring of parents with bipolar disorder: a case control study

BMC Psychiatry

Research Article

David Kemlink¹  Antonin Sebela²  Tomas Novak³  Michal Goetz⁴ 

[1] Department of Neurology, General Teaching Hospital and First Faculty of Medicine, Charles University in Prague, Katerinska 30, 128 21, Prague 2, Czech Republic;National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic;First Faculty of Medicine, Charles University in Prague, Katerinska 32, 121 08, Prague 2, Czech Republic;National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic;Third Faculty of Medicine, Charles University in Prague, 10, Ruska 87, 100 00, Prague, Czech Republic;Second Faculty of Medicine, Charles University in Prague, 5, V Uvalu 84, 15006, Prague, Czech Republic;Department of Child and Adolescent Psychiatry, Motol University Hospital, 5, V Uvalu 84, 15006, Prague, Czech Republic;

关键词: Actigraphy;    Offspring;    Bipolar disorder;    Sleep;    High-risk;    Child;    Adolescent;   

DOI  :  10.1186/s12888-017-1361-8

 received in 2016-08-14, accepted in 2017-05-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundImpairment of sleep and circadian rhythm is a typical feature of bipolar disorder (BD). We carried out an exploratory cross-sectional case-control study to extend the knowledge of sleep characteristics in offspring at risk for BD.MethodsWe investigated 42 offspring of bipolar parents (OB) (mean age 12.5 ± 3.2) and 42 sex and age matched comparison offspring of healthy parents. We administered the Pediatric Sleep Questionnaire, the Morningness/Eveningness Questionnaire and The General Behavior Inventory Sleep Subscale (GBISS) to assess circadian preference, and to identify sleep impairment symptoms. In addition, the participants completed 14 days of actigraphy to characterise sleep and wake patterns. The current psychopathology profile was assessed using Kiddie Schedule for Affective Disorders and Schizophrenia.ResultsPrevalence of sleep disturbance symptoms was higher among OB than controls (headache after waking up, 17.9% vs. 2.4%, p = 0.03; excessive daytime sleepiness, 38.5% vs. 10.0%, p = 0.004; apparent tiredness at wake-up times, 43.6% vs. 15.0%, p = 0.007 and nightmares, 21.6% vs. 2.4%, p = 0.01), but the differences between groups were not significant after adjusting for current psychopathology. OB had higher GBISS total score (parental version, p < 0.001; self-assessment, p = 0.07) than the controls. OB had higher preference for eveningness than the controls (p = 0.047). According to the actigraphy, OB had longer sleep onset latency (p = 0.048) than the controls.ConclusionEvidence suggests that the offspring of bipolar parents experience sleep disturbance symptoms, which was associated with psychopathology in this study. Prospective longitudinal sleep studies would clarify whether sleep disturbance could be a predictor of mood disorder onset in this high-risk population.

【 授权许可】

CC BY   
© The Author(s). 2017