Impact of rapid antigen detection testing on antibiotic prescription in acute pharyngitis in adults. FARINGOCAT STUDY: a multicentric randomized controlled trial

BMC Family Practice

Study Protocol

Mónica Gómez¹  Jordi Madurell²  Carl Llor³  Josep M Cots⁴  Montse Balagué⁵ 

[1] Primary Healthcare Center Doctor Josep Torner i Fors, Salut Maresme, Malgrat de Mar, Spain;Primary Healthcare Center Hostalric, Institut d'Assistència Sanitària de Girona, Breda-Hostalric, Spain;Primary Healthcare Center Jaume I, University Rovira i Virgili, Tarragona, Spain;Primary Healthcare Center La Marina, University of Barcelona, Barcelona, Spain;Primary Healthcare Center, Centre Penitenciari d'Homes. Catalonian Institute of Health, Barcelona, Spain;

关键词: Sore Throat;    Acute Otitis Medium;    Pharyngitis;    Rheumatic Fever;    Antibiotic Prescription;   

DOI  :  10.1186/1471-2296-11-25

 received in 2010-02-03, accepted in 2010-03-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAcute pharyngitis is one of the most frequent consultations to the general practitioner and in most of the cases an antibiotic is prescribed in primary care in Spain. Bacterial etiology, mainly by group A beta-hemolytic streptococcus (GABHS), accounts for 10-20% of all these infections in adults. The purpose of this study is to assess the impact of rapid antigen detection testing (RADT) to identify GABHS in acute pharyngitis on the utilization of antibiotics in primary care.Methods/designMulticentric randomized controlled trial in which antibiotic prescription between two groups of patients with acute pharyngitis will be compared. The trial will include two arms, a control and an intervention group in which RADT will be performed. The primary outcome measure will be the proportion of inappropriate antibiotic prescription in each group. Two hundred seventy-six patients are required to detect a reduction in antibiotic prescription from 85% in the control group to 75% in the intervention group with a power of 90% and a level of significance of 5%. Secondary outcome measures will be specific antibiotic treatment, antibiotic resistance rates, secondary effects, days without working, medical visits during the first month and patient satisfaction.DiscussionThe implementation of RADT would allow a more rational use of antibiotics and would prevent adverse effects of antibiotics, emergence of antibiotic resistance and the growth of inefficient health expenses.Trial registrationISRCTN23587778

【 授权许可】

CC BY   
© Madurell et al; licensee BioMed Central Ltd. 2010