Adult-Onset Still Disease (AOSD)

The Journal of the American Board of Family Medicine

Egambaram Senthilvel¹  Iyabode Adebambo¹  Aphrodite Papadakis¹  Michael McNamara² 

[1] Department of Family Medicine (ES, AP, IA);Department of Radiology (MM), MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH

关键词: Fever;    Arthritis;    Sore Throat;    Pharyngitis;    Adult-Onset Still Disease;    Case Report;   

DOI  :  10.3122/jabfm.2010.03.090157

学科分类：过敏症与临床免疫学

来源: The American Board of Family Medicine

【 摘 要 】

Adult-onset Still disease (AOSD) is an uncommon clinical entity that predominantly affects young adults. One of the most common presentations of the disease is fever of unknown origin. Early diagnosis can be difficult because fever of unknown origin is more commonly seen with other conditions such as malignancy or infection. Ambiguity in presentation and lack of serologic markers make diagnosis difficult.

We describe here an 18-year-old African-American man who presented with fever, sore throat, and arthritis at initial admission, with serology positive for both Mycoplasma pneumonia and Epstein-Barr infection. The patient was discharged without improvement. He was then readmitted with persistence of initial symptoms and, at that stage, he fulfilled the proposed diagnostic criteria of AOSD. The purpose of this case report is to describe the triggering infections that can initially mislead diagnosis and to review the literature about AOSD from a primary care perspective.

• Fever
• Arthritis
• Sore Throat
• Pharyngitis
• Adult-Onset Still Disease
• Case Report

Adult-onset Still disease (AOSD) was first described by Bywaters¹ in 1971. Still disease is a systemic inflammatory disorder of unknown etiology. AOSD is uncommon, with an estimated prevalence lower than 1 case per 100, 000 people.² Patients usually present with a high spiking fever, arthralgia or arthritis, sore throat, transient maculopapular rash, lymphadenopathy, hepatosplenomegaly, and serositis. Patients may or may not have all of the above symptoms at initial presentation.

【 授权许可】

Unknown   

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