Predictors of early adulthood hypertension during adolescence: a population-based cohort study

BMC Public Health

Research Article

Saeed Kalantari¹  Noushin Fahimfar²  Fereidoun Azizi³  Maryam Tohidi⁴  Samaneh Asgari⁴  Farzad Hadaegh⁴  Davood Khalili⁵ 

[1] Department of Endocrinology, Guilan University of Medical Sciences, Rasht, Iran;Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Present address: Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Postal Code: 1985717413, Tehran, Iran;

关键词: Hypertension;    Risk factors;    Adolescent;    Adult;    Anthropometry;    Wrist;    Cholesterol;   

DOI  :  10.1186/s12889-017-4922-3

 received in 2016-09-13, accepted in 2017-11-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSome longitudinal studies have shown that blood pressure tracks from adolescence to adulthood, yet there is limited evidence regarding the predictive factors of adulthood hypertension during adolescence. This study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) to investigate the role of some factors in adolescence, measured in the first examination (1999–2001), to predict adulthood hypertension in the 4th examination (2009–2011).MethodsOverall, 1579 subjects, aged 10–19 years, were used for the analysis of the current study. Mean age (SD) of participants at the baseline was 14.2 (2.5) years and 55% of them were female. A forward stepwise approach (p-value <0.2 for enter and >0.05 for removal) was considered to keep significant covariates among common variables including gender, body mass index, waist circumference, wrist and hip circumferences, fasting blood sugar, triglycerides, high density lipoprotein cholesterol, total cholesterol (TC), systolic (SBP) and diastolic blood pressure (DBP). Variance inflation factor (VIF) showed some multicollinearity for anthropometric variables (VIFs between 3.5 and 10). Multivariable logistic regression revealed that gender, blood pressure, wrist circumference and total cholesterol in adolescents are important predictors for adulthood hypertension.ResultsThe risk increased by 4% and 39% per each 10 mmHg and 1 mmol/L increase in SBP/DBP and TC, respectively; additionally, females had a 70% lower risk. Among anthropometric variables, wrist circumference remained in the model, with 50% per centimeter increase in the risk of hypertension.ConclusionsWrist circumferences and TC had significant roles in predicting hypertension through adolescence to adulthood.

【 授权许可】

CC BY   
© The Author(s). 2017