A case of rapidly progressive IgA nephropathy in a patient with exacerbation of Crohn’s disease

BMC Nephrology

Case Report

Yong-Jin Kim¹  Min Kyu Jung²  Ji-Young Choi³  Chan-Duck Kim³  Chung Hoon Yu³  Jang-Hee Cho³  Sun-Hee Park³  Hee-Yeon Jung³  Yong-Lim Kim³ 

[1] Department of Pathology, Yeungnam University School of Medicine, Daegu, South Korea;Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea;Division of Nephrology, Department of Internal Medicine, Kyungpook National University School of Medicine and Clinical Research Center for End Stage Renal Disease in Korea, 130 Dongduk-ro, Jung-gu, Daegu, South Korea;

关键词: Rapidly progressive IgA nephropathy;    Crohn’s disease;   

DOI  :  10.1186/1471-2369-13-84

 received in 2012-05-22, accepted in 2012-07-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIgA nephropathy has been reported as a renal involvement in Crohn’s disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn’s disease.Case presentationAn 18-year-old male diagnosed with Crohn’s disease underwent a hemicolectomy 2 years prior previously. He had maintained a state of Crohn’s disease remission with 5-aminosalicylic acid treatment. Four months prior to referral to the nephrology clinic, he experienced non-bloody diarrhea. He simultaneously developed proteinuria and microscopic hematuria with deterioration of renal function. Based on renal biopsy findings, the patient was diagnosed with crescentic IgA nephropathy. Immunostaining for interleukin-17 in renal tissue and previous exacerbated colonic ulcers was positive. Steroid pulse therapy was administered, followed by high-dose glucocorticoid and oral cyclophosphamide therapy. The patient’s renal function recovered and his gastrointestinal symptoms were alleviated.ConclusionsWe report a case of crescentic IgA nephropathy presenting with exacerbation of Crohn’s disease, and present a review of the literature focusing on the pathophysiologic relationship between these two conditions.

【 授权许可】

Unknown   
© Choi et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.