Social activity, cognitive decline and dementia risk: a 20-year prospective cohort study

BMC Public Health

Research Article

Carol Brayne¹  Riccardo E. Marioni²  Cecile Proust-Lima³  Helene Jacqmin-Gadda³  Helene Amieva⁴  Jean-Francois Dartigues⁴  Fiona E. Matthews⁵ 

[1] Department of Public Health and Primary Care, University of Cambridge, CB2 0SR, Cambridge, UK;Department of Public Health and Primary Care, University of Cambridge, CB2 0SR, Cambridge, UK;Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK;INSERM, Centre INSERM U897, F-33000, Bordeaux, France;University Bordeaux, ISPED, Centre INSERM U897, F-33000, Bordeaux, France;INSERM, Centre INSERM U897, F-33000, Bordeaux, France;University Bordeaux, ISPED, Centre INSERM U897, F-33000, Bordeaux, France;Service de Neurologie, Department of Clinical Neurosciences, CHU, Pellegrin, 33076, Bordeaux, France;MRC Biostatistics Unit, Institute of Public Health, CB2 0SR, Cambridge, UK;

关键词: Social engagement;    Social network;    Dementia;    Cognitive decline;    Longitudinal modelling;   

DOI  :  10.1186/s12889-015-2426-6

 received in 2015-01-19, accepted in 2015-10-16,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIdentifying modifiable lifestyle correlates of cognitive decline and risk of dementia is complex, particularly as few population-based longitudinal studies jointly model these interlinked processes. Recent methodological developments allow us to examine statistically defined sub-populations with separate cognitive trajectories and dementia risks.MethodsEngagement in social, physical, or intellectual pursuits, social network size, self-perception of feeling well understood, and degree of satisfaction with social relationships were assessed in 2854 participants from the Paquid cohort (mean baseline age 77 years) and related to incident dementia and cognitive change over 20-years of follow-up. Multivariate repeated cognitive information was exploited by defining the global cognitive functioning as the latent common factor underlying the tests. In addition, three latent homogeneous sub-populations of cognitive change and dementia were identified and contrasted according to social environment variables.ResultsIn the whole population, we found associations between increased engagement in social, physical, or intellectual pursuits and increased cognitive ability (but not decline) and decreased risk of incident dementia, and between feeling understood and slower cognitive decline. There was evidence for three sub-populations of cognitive aging: fast, medium, and no cognitive decline. The social-environment measures at baseline did not help explain the heterogeneity of cognitive decline and incident dementia diagnosis between these sub-populations.ConclusionsWe observed a complex series of relationships between social-environment variables and cognitive decline and dementia. In the whole population, factors such as increased engagement in social, physical, or intellectual pursuits were related to a decreased risk of dementia. However, in a sub-population analysis, the social-environment variables were not linked to the heterogeneous patterns of cognitive decline and dementia risk that defined the sub-groups.

【 授权许可】

CC BY   
© Marioni et al. 2015