Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

BMC Infectious Diseases

Research Article

Zhong-Ping Duan¹  Hong-Bin Song²  Mei-Lei Gu³  Yan-Wei Zhong³  Yi Dong³  Hong-Fei Zhang³  Yu-Kun Han³  Jin Li³  Shi-Shu Zhu³  Xiao-Yan Xing³  Xiao-Dong Li³ 

[1] Beijing You'an Hospital, Capital Medical University, Beijing, China;Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China;Pediatric Liver Disease Therapy and Research Center, Beijing 302 Hospital, Beijing, China;

关键词: hepatitis B virus;    genotypes/subgenoytpes;    drug mutation;    hepatic inflammation;    fibrosis;    pediatric patients;   

DOI  :  10.1186/1471-2334-11-262

 received in 2011-02-11, accepted in 2011-09-30,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.MethodsFour hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.ResultsAmong 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.ConclusionsThe pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.

【 授权许可】

Unknown   
© Zhong et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.