Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

BMC Infectious Diseases

Hong-Fei Zhang²  Shi-Shu Zhu²  Yu-Kun Han²  Mei-Lei Gu²  Xiao-Dong Li²  Xiao-Yan Xing²  Yi Dong²  Zhong-Ping Duan¹  Hong-Bin Song³  Jin Li²  Yan-Wei Zhong² 

[1] Beijing You'an Hospital, Capital Medical University, Beijing, China;Pediatric Liver Disease Therapy and Research Center, Beijing 302 Hospital, Beijing, China;Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China

关键词: pediatric patients;    fibrosis;    hepatic inflammation;    drug mutation;    genotypes/subgenoytpes;    hepatitis B virus;   

Others  :  1175587
DOI  :  10.1186/1471-2334-11-262

 received in 2011-02-11, accepted in 2011-09-30,  发布年份 2011

【 摘 要 】

Background

The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.

Methods

Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.

Results

Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.

Conclusions

The pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.

【 授权许可】

   
2011 Zhong et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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