Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

BMC Cancer

Research Article

Chongqi Jia¹  Baoquan Cheng²  Wenna Shi²  Yanjing Gao²  Lihui Su²  Yanqiu Yue²  Tao Zhou²  Zongli Zhang³  Xiuguo Zhang³  Xuting Zhi³  Caixia Li⁴  Qingliang Wang⁴ 

[1] Department of Epidemiology and Health Statistics, Shandong University, 250012, Jinan, China;Department of Gastroenterology, Qilu Hospital, School of Medicine, Shandong University, 250012, Jinan, China;Department of Hepatobiliary Surgery, Qilu Hospital, School of Medicine, Shandong University, 250012, Jinan, China;Department of Intervention, Qilu Hospital, School of Medicine, Shandong University, 250012, Jinan, China;

关键词: Hepatocellular carcinoma;    Prognosis;    Staging system;    Independent predictors;    Overall survival;   

DOI  :  10.1186/s12885-016-2420-0

 received in 2015-12-14, accepted in 2016-06-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSeveral staging systems have been developed to evaluate patients with hepatocellular carcinoma (HCC), including the China Staging System (CS), the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system, and seventh edition; the Barcelona Clinic Liver Cancer (BCLC) staging system, and Cancer of the Liver Italian Program (CLIP) staging system. The optimal staging system for to evaluate patients in China with HCC has not been determined. This study was designed to determine the optimal staging system for predicting patient prognosis by comparing the performances of these four staging systems in a cohort of Chinese patients with HCC.MethodsThis study enrolled 307 consecutive Chinese patients with HCC in Shandong Province. The performances of the CS, TNM, BCLC, and CLIP staging systems were compared and ranked using a concordance index. Predictors of survival were identified using univariate and multivariate Cox model analyses.ResultsThe mean overall survival of the patient cohort was 12.08 ± 11.87 months. Independent predictors of survival included tumor size, number of lesions, tumor thromboses, cirrhosis, serum albumin level and serum total bilirubin level. Compared with the other three staging systems, the CS staging system showed optimal performance as an independent predictor of patient survival. The BCLC staging system showed the poorest performance; its treatment algorithm was not suitable for patients in this study.ConclusionsCS was the most suitable staging system for predicting survival of patients with HCC in China.

【 授权许可】

CC BY   
© The Author(s). 2016