Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

BMC Cancer

Research Article

Takeshi Sasaki¹  Hideyuki Terao²  Masaki Narahara³  Tomoyuki Tadenuma⁴  Syusei Fusayasu⁵  Kazuhide Makiyama⁶  Hiroki Ito⁶  Jun Kasuga⁶  Masahiro Yao⁶  Takashi Kawahara⁷  Daiji Takamoto⁸  Sachi Fukui⁹  Koji Izumi^1,10  Takashi Tokita^1,11  Hiroshi Miyamoto^1,12  Yusuke Hattori^1,13  Yasuhide Miyoshi^1,13  Jun-ichi Teranishi^1,13  Hiroji Uemura^1,13  Yasushi Yumura^1,13 

[1] Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan;Department of Urology, Fujisawa City Hospital, Fujisawa, Japan;Department of Urology, International Goodwill Hospital, Yokohama, Japan;Department of Urology, Kanagawa Cancer Center, Yokohama, Japan;Department of Urology, Yamato Municipal Hospital, Yamato, Japan;Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 2360004, Yokohama, Kanagawa, Japan;Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 2360004, Yokohama, Kanagawa, Japan;Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan;Department of Urology, Yokohama Minami Kyosai Hospital, Yokohama, Japan;Department of Urology, Yokohama Minato Red Cross Hospital, Yokohama, Japan;Department of Urology, Yokohama Municipal Citizen’s Hospital, Yokohama, Japan;Department of Urology, Yokosuka Kyosai Hospital, Yokosuka, Japan;Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, USA;Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan;

关键词: Penile cancer;    Biomarker;    Neutrophil-to-lymphocyte ratio;    Immunohistochemistry;   

DOI  :  10.1186/s12885-016-2443-6

 received in 2016-01-05, accepted in 2016-06-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer.MethodsA total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer.ResultsThe median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR.ConclusionsThe pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.

【 授权许可】

CC BY   
© The Author(s). 2016