Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients

BMC Cancer

Research Article

Anthony J. Gill¹  Tristan Dodds¹  Alex Guminski²  Carol R. Haddad³  Mark Stevens⁴  Thomas Eade⁴  Michael Back⁴  David Veivers⁵  Stephen J. Clarke⁶  Kellie A. Charles⁷  Benjamin D. W. Harris⁷ 

[1] Department of Anatomical Pathology, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, University of Sydney, 2006, Sydney, NSW, Australia;Department of Medical Oncology, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;Northern Clinical School (Medicine), University of Sydney, 2006, Sydney, NSW, Australia;Department of Surgery, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;Northern Clinical School (Medicine), University of Sydney, 2006, Sydney, NSW, Australia;Department of Medical Oncology, Royal North Shore Hospital, 2065, St Leonards, NSW, Australia;School of Medical Sciences (Pharmacology) and Bosch Institute, University of Sydney, 2006, Sydney, NSW, Australia;

关键词: Systemic inflammation;    Prognosis;    Head and neck cancer;    Neutrophil-to-lymphocyte ratio;    Overall survival;    Recurrence free survival;   

DOI  :  10.1186/s12885-016-2089-4

 received in 2015-09-08, accepted in 2016-01-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCurrently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clinical outcomes in a heterogeneous cohort of HNSCC cancer patients.MethodsWe performed a retrospective analysis to identify associations between NLR and clinicopathological features to recurrence free survival (RFS) and overall survival (OS). Univariate analysis was used to identify associations and selected variables were included in multivariable Cox regression analysis to determine predictive value.ResultsA total of 145 patients with stage I-IV HNSCC that had undergone radiotherapy were analysed. Seventy-six of these patients had oropharyngeal cancer and 69 had non-oropharyngeal HNSCC and these populations were analysed separately. NLR was not associated to any clinicopathological variable. On univariate analysis, NLR showed associations with RFS and OS in both sub-populations. Multivariable analysis showed patients with NLR > 5 had shortened OS in both sub-populations but NLR > 5 only predicted RFS in oropharyngeal patients. Poor performance status predicted OS in both sub-populations and current smokers had shortened OS and RFS in non-oropharyngeal patients.ConclusionsThe results show patients with NLR > 5 predict for shorter overall survival. Further prospective validation studies in larger cohorts are required to determine the clinical applicability of NLR for prognostication in HNSCC patients.

【 授权许可】

CC BY   
© Charles et al. 2016