Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study

BMC Nephrology

Research Article

Jørgen Schei¹  Vidar Tor Nyborg Stefansson¹  Trond Geir Jenssen²  Toralf Melsom³  Bjørn Odvar Eriksen³ 

[1] Metabolic and Renal Research Group, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway;Metabolic and Renal Research Group, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway;Department of Organ Transplantation, Oslo University Hospital, Oslo, Norway;Metabolic and Renal Research Group, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway;Section of Nephrology, University Hospital of North Norway, Tromsø, Norway;

关键词: Body mass index;    Chronic kidney disease;    Glomerular filtration rate;    Glomerular hyperfiltration;    Waist circumference;    Waist-hip ratio;   

DOI  :  10.1186/s12882-016-0386-4

 received in 2016-06-21, accepted in 2016-11-01,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundObesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C.Methods1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other.ResultsIn multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase.ConclusionsCentral obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC.

【 授权许可】

CC BY   
© The Author(s). 2016