The impact of IgM deposits on the outcome of Nephrotic syndrome in children

BMC Nephrology

Research Article

Arvydas Laurinavicius¹  Rimante Cerkauskiene²  Augustina Jankauskiene²  Sandra Juozapaite² 

[1] Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania;National Center of Pathology, affiliate of Vilnius University Hospital Santariskiu Clinics, P. Baublio str. 5, 08406, Vilnius, Lithuania;Institute of Clinical Medicine, Faculty of medicine, Vilnius University, M.K.Ciurlionio srt. 21, 03101, Vilnius, Lithuania;

关键词: Nephrotic syndrome;    IgM deposition;    Renal biopsy;    Minimal change disease;    Focal segmental glomerulosclerosis;   

DOI  :  10.1186/s12882-017-0674-7

 received in 2016-11-12, accepted in 2017-07-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe significance of IgM deposits in glomerular mesangium has been controversial since they were first described due to the variations in the both the definitions used and described impact on clinical outcome. The aim of our study was to evaluate the significance of the IgM deposits in the glomerular mesangium for outcomes of nephrotic syndrome (NS) in children.MethodsForty-five children with NS who underwent renal biopsy at tertiary pediatric hospital from January 1st, 2000 to December 31st, 2015 and the pathology diagnosis of minimal change disease, focal segmental glomerulosclerosis and mesangial hypercellularity (MH) were retrospectively analyzed. IgM positivity was defined as ≥1+ imunofluorescence with predominantly mesangial distribution. The patients were stratified into IgM-positive (n = 18) and IgM-negative (n = 27).ResultsAt the end of the median follow-up 4.5 years (range 0.17–13.14), the IgM-positive group was represented by 11 patients (61.1%) in remission, 3 patients (16.7%) with active disease and normal kidney function, 2 (11.1%) patients with active disease and impaired kidney function, 2 (11.1%) patients on renal replacement therapy. Accordingly, the IgM-negative group included 13 patients (48.1%) in remission, 12 (44.4%) with active disease and normal kidney function, 1 (3.7%) with active disease and impaired kidney function, 1 (3.7%) on renal replacement therapy, with no statistical significance between groups (p = 0.186).ConclusionsThis study did not reveal significant differences of the disease outcomes between IgM-positive and IgM-negative groups.

【 授权许可】

CC BY   
© The Author(s). 2017