Early detection of memory impairment in people over 65 years old consulting at Health Examination Centers for the French health insurance: the EVATEM protocol

BMC Geriatrics

Study Protocol

Isabelle Rouch¹  Virginie Dauphinot¹  Pierre Krolak-Salmon²  Catherine Sass³  Olivier Beauchet⁴  Bienvenu Bongue⁵  Christiane Vannier-Nitenberg⁶  Bruno Fantino⁷ 

[1] Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Lyon, France;Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Lyon, France;Inserm U1028; CNRS UMR5292; Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon, France;University Lyon 1, Lyon, France;Centre Technique d’Appui et de Formation des Centres d’Examens de Santé (CETAF), Saint-Étienne, France;Centre Technique d’Appui et de Formation des Centres d’Examens de Santé (CETAF), Saint-Étienne, France;Département de Médecine Interne et Gérontologie clinique, CHU D’Angers, Angers, France;Centre Technique d’Appui et de Formation des Centres d’Examens de Santé (CETAF), Saint-Étienne, France;Laboratory EA4607 SNA-EPIS, Jean Monnet University of Saint-Etienne, PRES Lyon, Saint-Etienne, France;Centre d’Examens de Santé de la CPAM du Rhône, Lyon, France;Département de Médecine Interne et Gérontologie clinique, CHU D’Angers, Angers, France;Direction de la Performance et de la Gestion des Risques- Agence Régionale de santé de Lorraine, Nancy, France;

关键词: Early diagnosis;    Alzheimer’s disease;    Memory complaint;    Mild cognitive impairment;   

DOI  :  10.1186/1471-2318-13-55

 received in 2013-03-17, accepted in 2013-04-20,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundOnly half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive tests for their predictive ability to diagnose mild cognitive impairments and Alzheimer’s disease and related disorders. For people aged 65 years or over, presenting with a memory complaint, these tests can be performed easily during a preventative consultation.Method/designThe EVATEM (évaluation des troubles de l’équilibre et de la mémoire (evaluation of balance and memory problems)) cohort study was designed to prospectively assess the predictive value of tests for the diagnosis of mild cognitive impairments and Alzheimer’s disease in elderly subjects aged 65 years or over. Subjects were recruited from three health examination centers that are part of the French health insurance system. If a memory complaint was identified (using a dedicated questionnaire), the five-word test, the cognitive disorders examination test and the verbal fluency test were administered during a preventative consultation. A memory consultation was performed at a University Hospital to diagnosis any potential cognitive disorder and a one-year follow-up consultation was also scheduled. We recorded 2041 cases of memory complaint at our Health Examination Centers. Cognitive tests were refused by 33.6% of people who had a memory complaint. The number of subjects sent to a University Hospital memory consultation was 832 and 74.5% of them completed this consultation. The study population therefore includes 620 subjects.DiscussionTests for the early diagnosis of a mild cognitive impairment or Alzheimer’s disease and related disorders should be used in centers dedicated to disease prevention. These should guide subjects with memory impairment to full memory consultations at hospitals and improve the access to early medical and behavioral support.Trial registrationClinicalTrials.gov:NCT01316562

【 授权许可】

CC BY   
© Vannier-Nitenberg et al.; licensee BioMed Central Ltd. 2013