Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary thyroid carcinoma

BMC Cancer

Research Article

Ou Huang¹  Quan Li²  OuChen Wang²  JinMiao Qu²  YiFei Pan²  DuPing Huang²  GuiLong Guo²  Cun Jin²  YouQun Xiang²  XiaoQu Hu²  XiaoHua Zhang²  ShuMei Zhou²  Jie You²  Kai Yang²  XueMin Chen²  WeiLi Wu³ 

[1] Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 200025, Shanghai, China;Department of Surgical Oncology, the First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang Province, China;Department of Surgical Oncology, the First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang Province, China;Department of Surgical Oncology, the Third Affiliated Hospital of Wenzhou Medical College, Zhejiang Province, 325200, Wenzhou, China;

关键词: Sentinel Lymph Node;    Methylene Blue;    Thyroid Cancer;    Sentinel Lymph Node Biopsy;    Papillary Thyroid Cancer;   

DOI  :  10.1186/1471-2407-11-386

 received in 2010-09-17, accepted in 2011-09-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundSentinel lymph node (SLN) biopsy has been used to assess patients with papillary thyroid carcinoma (PTC). To achieve its full potential the rate of SLN identification must be as close to 100 percent as possible. In the present study we compared the combination of preoperative lymphoscintigraphy scanning by sulfur colloid labeled with 99 m Technetium, gamma-probe guided surgery, and methylene blue with methylene blue, alone, for sentinel node identification in younger women with unilateral low-risk PTC.MethodsFrom January 2004 to January 2007, 90 female patients, ages 23 to 44 (mean = 35), with unilateral low-risk PTC (T1-2N0M0) were prospectively studied. Mean tumor size was 1.3 cm (range, 0.8-3.7 cm). All patients underwent unilateral modified neck dissection. Prior to surgery, patients had, by random assignment, identification and biopsy of SLNs by methylene blue, alone (Group 1), or by sulfur colloid labeled with 99 m Technetium, gamma-probe guided surgery and methylene blue (Group 2).ResultsIn the methylene blue group, SLNs were identified in 39 of 45 patients (86.7%). Of the 39 patients, 28 (71.8%) had positive cervical lymph nodes (pN+), and 21 patients (53.8%) had pSLN+. In 7 of the 28 pN+ patients (25%), metastases were also detected in non-SLN, thus giving a false-negative rate (FNR of 38.9% (7/18), a negative predictive value (NPV) of 61.1% (11/18), and an accuracy of 82.1% (32/39). In the combined technique group, the identification rate (IR) of SLN was 100% (45/45). Of the 45 patients, 27 (60.0%) had pN+, 24 (53.3%) had pSLN+. There was a FNR of 14.3% (3/21), a NPV of 85.7% (18/21), and an accuracy of 93.3% (42/45). The combined techniques group was significantly superior to the methylene blue group in IR (p = 0.035). There were no significant differences between two groups in sensitivity, specificity, NPV, or accuracy. Location of pN+ (55 patients) in 84 patients was: level I and V, no patients; level II, 1 patient (1.2%); level III, 6 patients (7.2%); level III and IV, 8 patients (9.5%); level IV, alone, 8 patients (9.5%); level VI, 32 patients (38.1%). In all 90 patients, IR of SLN was 93.3%, FNR, 25.6%, NPV, 74.4%, and accuracy rate, 88.1 percent.ConclusionsCompared to a single technique, there was a significantly higher SLN identification rate for the combined technique in younger female with ipsilateral, low-risk PTC (T1-2N0M0). Thus, a combined SLN biopsy technique seems to more accurately stage lymph nodes, with better identification of SLN located out of the central compartment. Regardless of the procedure used, the high FNR renders the current SLN techniques unsuitable for routine practice. Based on these results, prophylactic node dissection of level VI might be considered because 38.1% of our patients had such node metastases.

【 授权许可】

Unknown   
© Huang et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.