Increased shedding of HU177 correlates with worse prognosis in primary melanoma

Journal of Translational Medicine

Research

Michelle W Ma¹  Iman Osman¹  Heather K Hamilton¹  Daniel Krich¹  Amy E Rose¹  Leonard Liebes²  Russell S Berman³  Richard L Shapiro³  Peter C Brooks⁴  Paul J Christos⁵  Madhu Mazumdar⁵ 

[1] Department of Dermatology, New York University School of Medicine, New York, NY, USA;Department of Medicine, New York University School of Medicine, New York, NY, USA;Department of Surgery, New York University School of Medicine, New York, NY, USA;Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, NY, USA;Maine Medical Center Research Institute, Center for Molecular Medicine, 81 Research Drive Scarborough, 04074, ME, USA;Division of Biostatistics and Epidemiology, Weill Medical College of Cornell University, New York, NY, USA;

关键词: Melanoma;    Vascular Endothelial Growth Factor;    Overall Survival;    Sentinel Lymph Node;    Sentinel Lymph Node Biopsy;   

DOI  :  10.1186/1479-5876-8-19

 received in 2009-11-13, accepted in 2010-02-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIncreased levels of cryptic collagen epitope HU177 in the sera of melanoma patients have been shown to be associated with thicker primary melanomas and with the nodular histologic subtype. In this study, we investigate the association between HU177 shedding in the sera and clinical outcome in terms of disease-free survival (DFS) and overall survival (OS).MethodsSerum samples from 209 patients with primary melanoma prospectively enrolled in the Interdisciplinary Melanoma Cooperative Group at the New York University Langone Medical Center (mean age = 58, mean thickness = 2.09 mm, stage I = 136, stage II = 41, stage III = 32, median follow-up = 54.9 months) were analyzed for HU177 concentration using a validated ELISA assay. HU177 serum levels at the time of diagnosis were used to divide the study cohort into two groups: low and high HU177. DFS and OS were estimated by Kaplan-Meier survival analysis, and the log-rank test was used to compare DFS and OS between the two HU177 groups. Multivariate Cox proportional hazards regression models were employed to examine the independent effect of HU177 category on DFS and OS.ResultsHU177 sera concentrations ranged from 0-139.8 ng/ml (mean and median of 6.2 ng/ml and 3.7 ng/ml, respectively). Thirty-eight of the 209 (18%) patients developed recurrences, and 34 of the 209 (16%) patients died during follow-up. Higher HU177 serum level was associated with an increased rate of melanoma recurrence (p = 0.04) and with increasing mortality (p = 0.01). The association with overall survival remained statistically significant after controlling for thickness and histologic subtype in a multivariate model (p = 0.035).ConclusionsIncreased shedding of HU177 in the serum of primary melanoma patients is associated with poor prognosis. Further studies are warranted to determine the clinical utility of HU177 in risk stratification compared to the current standard of care.

【 授权许可】

Unknown   
© Hamilton et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.