Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

BMC Complementary and Alternative Medicine

Research Article

Dastagir Nida¹  Faheem Aisha¹  Jabeen Almas¹  Simjee U. Shabana²  Marius Mbiantcha³ 

[1] Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Karachi, Pakistan;H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Karachi, Pakistan;Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;

关键词: Piptadeniastrum africanum;    Immunomodulation;    Oxidative burst;    T-cell proliferation;    Cytotoxicity;    Rheumatoid arthritis;   

DOI  :  10.1186/s12906-017-1623-5

 received in 2016-09-12, accepted in 2017-02-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundRheumatoid arthritis, disease of unknown causes is a rheumatic and autoimmune pathology, recognised for its increasing frequency and its adverse consequences. It is a disease that occurs in most cases between 50 and 60 years and women are more affected than men. This study aimed at evaluating immunomodulatory and anti-arthritis capacity of aqueous and methanol extracts of stem bark of Piptadeniastrum africanum (Mimosaceae).MethodsROS production from phagocytes, proliferation of T-cells, TNF-α and IL-1β production and cytotoxicity were performed by using chemiluminescence technique, liquid scintillation counter, ELISA and MTT assay, respectively. Anti-arthritic activity was evaluated using a model of adjuvant induced arthritis.ResultsMethanol and aqueous extracts of Piptadeniastrum africanum significantly (P < 0.001) inhibited extracellular and intracellular ROS production. These extracts also possess significant (P < 0.001) inhibitory activity on T-cell proliferation other than reduced TNF-α and IL-1β production. Piptadeniastrum africanum also significantly exhibited antiarthritic activity in complete Freund’s adjuvant induced arthritis in rat associated with a significant anti-inflammatory and anti-hyperalgesia activity.ConclusionsImmunomodulatory, anti-inflammatory, antihyperalgesia and anti-arthritis potential revealed in this study approve that, Piptadeniastrum africanum is a plant rich in compounds with anti-arthritic properties.

【 授权许可】

CC BY   
© The Author(s). 2017