Comparing oil based ointment versus standard practice for the treatment of moderate burns in Greece: a trial based cost effectiveness evaluation

BMC Complementary and Alternative Medicine

Research Article

Fotini N Antonopoulou¹  Evangelia G Tsati²  John D Ioannovich³  Georgia C H Spyropoulou⁴  Vilelmine J Carayanni⁵ 

[1] "G. Gennimatas" General State Hospital of Athens, 154 Mesogion Avenue, Greece;5 Haras St., 1523, Halandri, Athens, Greece;Author deceased. In memory of Professor J. Ioannovich †(2003), Department of Plastic Surgery, Microsurgery and Burn Center, "G.Gennimatas" General State Hospital of Athens, 154 Mesogion Avenue, Athens, Greece;Department of Plastic Surgery, Thriasion Hospital, G. Gennimata Avenue, 19018, Magoula Attiki, Greece;Department of Public Health, Faculty of Health and Caring Professions Technological Educational Institute of Athens, Saint Spyridonos Street, 2210, Egaleo, Greece;

关键词: Berberine;    Povidone Iodine;    Partial Thickness;    Cost Effectiveness Acceptability Curve;    Nursing Personnel;   

DOI  :  10.1186/1472-6882-11-122

 received in 2011-03-06, accepted in 2011-12-01,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe local treatment of burn wounds has long been a subject of debate. The objective of this study was to compare the cost and the effectiveness of Moist Exposed Burn Ointment -MEBO versus a combination of povidone iodine plus bepanthenol cream for partial thickness burns.MethodsThe study was carried out in the Burn Center of a state hospital in Athens, Greece. 211 patients needing conservative therapy were prospectively selected according to the depth of the burn wound. The treatment was allocated according to the Stratified Randomization Design. The outcomes measured were mean cost of in-hospital stay, rate of complications, time of 50% wound healing, pain scores, in hospital stay diminution. We have adopted a societal perspective.ResultsIn the total groups MEBO presented lower cost, (although not significantly different: p = 0.10) and better effectiveness. The data suggest that MEBO is the dominant therapy for superficial partial burn wound with significantly lower costs and significantly higher effectiveness due to a lesser time of recovery and consequently lower time of hospitalization and follow-up. MEBO presented similar percentages of complications with the comparator, lower pain levels and smaller time of no healthy appearance of the burn limits for superficial partial thickness burns.ConclusionsThe data suggested that topical application of MEBO may be considered for further investigation as a potential first-line treatment modality for superficial partial thickness burns.Trial registrationThe trial has been registered on the International Standard Randomised Controlled Trial Number Register (ISRCTN) and given the registration number ISRCTN74058791.

【 授权许可】

CC BY   
© Carayanni et al; licensee BioMed Central Ltd. 2011