Pharmacological basis for the use of Hypericum oblongifolium as a medicinal plant in the management of pain, inflammation and pyrexia

BMC Complementary and Alternative Medicine

Research Article

Haroon Khan¹  Naveed Muhammad¹  Muhammad Shahid²  Muhammad Saeed³  Farah Gul³  Naila Raziq⁴ 

[1] Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan;Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan;Department of Pharmacy, University of Peshawar, 25120, Peshawar, Pakistan;Department of Pharmacy, University of Peshawar, 25120, Peshawar, Pakistan;Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan;

关键词: Hypericum oblongifolium;    Methanol extract;    Antinociceptive;    Anti-inflammatory;    Antipyretic activities;   

DOI  :  10.1186/s12906-016-1018-z

 received in 2015-04-23, accepted in 2016-01-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects. Therefore, new effective agents are the most wanted. The present study investigates the anti-nociceptive, anti-inflammatory and antipyretic activities of crude methanol extract of Hypericum oblongifolium.MethodsIn vivo acetic acid induced writhing and hot plate tests were used for antinociceptive effects at 100, 200 and 300 mg/kg i.p. The anti-inflammatory and antipyretic potential of methanol extract were tested in carrageenan induced paw edema in mice and yeast induced hyperthermia respectively.ResultsThe extract doses of 100, 200 and 300 mg/kg i.p. revealed significant inhibitory effect (P < 0.001) in acetic acid induced writhing test. Pretreatment of extract at doses of 100, 200 and 300 mg/kg i.p. produced significant anti-inflammatory effect (P < 0.001) in the carrageenan induced paw edema. The methanol extract also showed significant antipyretic effect in yeast induced hyperthermia in mice during various assessment times.ConclusionsThe methanol extract of H. oblongifolium showed significant anti-nociceptive, anti-inflammatory and antipyretic effects in various animal models and thus validates the traditional uses of the plant in said conditions.

【 授权许可】

CC BY   
© Raziq et al. 2016