Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats

BMC Complementary and Alternative Medicine

Research Article

Hyunsu Bae¹  Hyunju Lee²  Minsook Ye²  Hye-Jung Lee²  Dae-Hyun Hahm²  Insop Shim² 

[1] Department of Physiology, College of Korean Medicine, Kyung Hee University, 130-701, Seoul, Republic of Korea;Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, 26 KyungHee-daero, 130-701, Seoul, South Korea;

关键词: Paecilomyces japonica (PJ;    Nicotine;    Locomotor activity;    Development sensitization;    c-Fos;    Tyrosine hydroxylase (TH);    Dopamine;   

DOI  :  10.1186/s12906-015-0739-8

 received in 2014-10-07, accepted in 2015-06-22,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMany studies have demonstrated that repeated injections of nicotine can produce progressive increases in locomotor activity and enhanced expression of c-fos and tyrosine hydroxylase (TH) in brain dopaminergic areas. Paecilomyces japonica (PJ) is a herbal medicine that is commonly used to treat opiate and other addictions in Eastern Asia. However, its influence on nicotine addiction has not been examined. This study was carried out to investigate the effects of PJ on repeated nicotine-induced behavioral sensitization of locomotor activity and c-Fos and TH expression in the rat brain using immunohistochemistry.MethodsRats were pretreated with PJ (10, 25, 50, 100, and 200 mg/kg, intraperitoneally) 30 min before repeated injections of nicotine (0.4 mg/kg, subcutaneously, twice daily for 7 days). Locomotor activity was measured in rats during 7-day nicotine treatments. On the seventh day, c-Fos and TH expression were assessed.ResultsPretreatment with PJ decreased the development of nicotine-induced sensitization, c-Fos expression in the nucleus accumbens and striatum, and TH expression in the ventral tegmental area. PJ decreased nicotine-induced locomotor activity by modulating brain dopaminergic systems.ConclusionThe results of the present study suggest that PJ may be a useful agent for preventing and treating nicotine addiction.

【 授权许可】

Unknown   
© Ye et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.