Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats

BMC Complementary and Alternative Medicine

Insop Shim²  Hye-Jung Lee²  Dae-Hyun Hahm²  Hyunsu Bae¹  Hyunju Lee²  Minsook Ye² 

[1]Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea

[2]Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, 26 KyungHee-daero, Seoul 130-701, South Korea

关键词: Dopamine;    Tyrosine hydroxylase (TH);    c-Fos;    Development sensitization;    Locomotor activity;    Nicotine;    Paecilomyces japonica (PJ);   

Others  :  1220036
DOI  :  10.1186/s12906-015-0739-8

 received in 2014-10-07, accepted in 2015-06-22,  发布年份 2015

【 摘 要 】

Background

Many studies have demonstrated that repeated injections of nicotine can produce progressive increases in locomotor activity and enhanced expression of c-fos and tyrosine hydroxylase (TH) in brain dopaminergic areas. Paecilomyces japonica (PJ) is a herbal medicine that is commonly used to treat opiate and other addictions in Eastern Asia. However, its influence on nicotine addiction has not been examined. This study was carried out to investigate the effects of PJ on repeated nicotine-induced behavioral sensitization of locomotor activity and c-Fos and TH expression in the rat brain using immunohistochemistry.

Methods

Rats were pretreated with PJ (10, 25, 50, 100, and 200 mg/kg, intraperitoneally) 30 min before repeated injections of nicotine (0.4 mg/kg, subcutaneously, twice daily for 7 days). Locomotor activity was measured in rats during 7-day nicotine treatments. On the seventh day, c-Fos and TH expression were assessed.

Results

Pretreatment with PJ decreased the development of nicotine-induced sensitization, c-Fos expression in the nucleus accumbens and striatum, and TH expression in the ventral tegmental area. PJ decreased nicotine-induced locomotor activity by modulating brain dopaminergic systems.

Conclusion

The results of the present study suggest that PJ may be a useful agent for preventing and treating nicotine addiction.

【 授权许可】

   
2015 Ye et al.

【 图 表 】

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