Synchronous well differentiated neuroendocrine tumour and gastrointestinal stromal tumour of the stomach: a case report

BMC Gastroenterology

Case Report

Periklis G Foukas¹  Ioannis G Panayiotides¹  Vassilis D Samaras¹  Vassilia Leontara¹  Eirini M Tsompanidi¹  Anastasios Machairas²  Dimitrios Tsapralis²  Konstantinos Triantafyllou³ 

[1] 2ndDepartment of Pathology, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), (12462), Chaidari, Athens, Greece;3rdDepartment of Surgery, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), (12462), Chaidari, Athens, Greece;Gastroenterology Unit, 2ndDepartment of Internal Medicine - Propedeutic, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), (12462), Chaidari, Athens, Greece;

关键词: stomach;    neuroendocrine tumour;    GIST;   

DOI  :  10.1186/1471-230X-11-27

 received in 2010-10-25, accepted in 2011-03-24,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundWell differentiated neuroendocrine tumours (carcinoids), arising from cells of the diffuse neuroendocrine system, represent the most commonly encountered gastric endocrine tumours. Gastrointestinal stromal tumours (GISTs), which stem from interstitial Cajal cells located within the wall of the gastrointestinal tract and have a characteristic immunoreactivity for CD117 (c-kit protein), account for the majority of gastrointestinal mesenchymal neoplasms. Simultaneous occurrence of a GIST with a well differentiated neuroendocrine tumour in the stomach is very rare.MethodsClinical history, endoscopy and histopathological findings were utilized for our diagnostic considerations.ResultsWe report the coexistence of a high risk GIST with a well differentiated neuroendocrine tumour of benign clinical behavior, both located in the stomach, in a 62-year-old man previously operated for a gastric well differentiated neuroendocrine tumour with uncertain malignant behaviour.ConclusionsEven single well differentiated, sporadic, NETs of small size may coexist with GISTs. An appropriate initial therapeutic approach combined with a scrupulous follow-up seems to play a significant role in terms of preventing a metastatic disease.

【 授权许可】

CC BY   
© Samaras et al; licensee BioMed Central Ltd. 2011