Synchronous well differentiated neuroendocrine tumour and gastrointestinal stromal tumour of the stomach: a case report

BMC Gastroenterology

Ioannis G Panayiotides²  Anastasios Machairas³  Eirini M Tsompanidi²  Dimitrios Tsapralis³  Vassilia Leontara²  Konstantinos Triantafyllou¹  Periklis G Foukas²  Vassilis D Samaras² 

[1] Gastroenterology Unit, 2ndDepartment of Internal Medicine - Propedeutic, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), Chaidari, Athens, (12462), Greece;2ndDepartment of Pathology, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), Chaidari, Athens, (12462), Greece;3rdDepartment of Surgery, University of Athens Medical School ("Attikon" University Hospital), (1 Rimini), Chaidari, Athens, (12462), Greece

关键词: GIST;    neuroendocrine tumour;    stomach;   

Others  :  1114613
DOI  :  10.1186/1471-230X-11-27

 received in 2010-10-25, accepted in 2011-03-24,  发布年份 2011

【 摘 要 】

Background

Well differentiated neuroendocrine tumours (carcinoids), arising from cells of the diffuse neuroendocrine system, represent the most commonly encountered gastric endocrine tumours. Gastrointestinal stromal tumours (GISTs), which stem from interstitial Cajal cells located within the wall of the gastrointestinal tract and have a characteristic immunoreactivity for CD117 (c-kit protein), account for the majority of gastrointestinal mesenchymal neoplasms. Simultaneous occurrence of a GIST with a well differentiated neuroendocrine tumour in the stomach is very rare.

Methods

Clinical history, endoscopy and histopathological findings were utilized for our diagnostic considerations.

Results

We report the coexistence of a high risk GIST with a well differentiated neuroendocrine tumour of benign clinical behavior, both located in the stomach, in a 62-year-old man previously operated for a gastric well differentiated neuroendocrine tumour with uncertain malignant behaviour.

Conclusions

Even single well differentiated, sporadic, NETs of small size may coexist with GISTs. An appropriate initial therapeutic approach combined with a scrupulous follow-up seems to play a significant role in terms of preventing a metastatic disease.

【 授权许可】

   
2011 Samaras et al; licensee BioMed Central Ltd.

【 图 表 】

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