BMC Urology | |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer | |
Research Article | |
Jibril Oyekunle Bello1  | |
[1] Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria; | |
关键词: Prostate cancer; Androgen deprivation therapy; PSA kinetics; PSA nadir; Black men; Sub Saharan Africa; | |
DOI : 10.1186/s12894-017-0228-0 | |
received in 2016-11-11, accepted in 2017-05-23, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundThough it is well established that black men are at higher risk of prostate cancer (PCa) very little is known about the disease in native sub Saharan black men. Newly diagnosed metastatic PCa patients treated with primary androgen deprivation therapy were identified and predictors of progression-free survival (PFS) assessed.MethodsPatients diagnosed with metastatic PCa between 2010 and 2015 in a sub Saharan black population were included in the study. Primary outcome measure was PFS defined as time from primary androgen deprivation therapy to clinical progression or death. Demographic, clinical and PSA kinetic variables were evaluated for their prognostic power using Cox proportional hazard regression models.ResultsSeventy-nine patients met the eligibility criteria and were analyzed. Median age, median overall survival and PFS was 69 years, 40 months and 27 months respectively. A PSA nadir >4 ng/mL was found to predict an earlier clinical progression. Median PFS was shorter in those with PSA nadir >4 ng/mL (15 months) compared to those with PSA nadir ≤4 ng/mL (29 months); log rank p value = 0.003.ConclusionsThe PSA nadir achieved following primary androgen deprivation therapy predicts progression-free survival in sub Saharan black men newly diagnosed with metastatic PCa. PSA nadir >4 ng/mL was found to be associated with a more rapid clinical progression.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311094708340ZK.pdf | 662KB | download |
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