Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study

BMC Medical Imaging

Research Article

Guohua Zheng¹  Zhenyu Xiong²  Rui Xia²  Yuhui Zheng²  Wenji Zhou²  Jing Tao²  Lidian Chen³  Moyi Li⁴  Shengxiang Liang⁵  Qin Wang⁶ 

[1] College of Health Information Technology and Management, Shanghai University of Medicine & Health Sciences, 201318, Shanghai, China;College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China;College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China;Fujian Key Laboratory of Rehabilitation Technology, 350003, Fuzhou, China;Department of Rehabilitation, The First Affiliated Hospital of Nanchang University, 330006, Nanchang, China;College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China;Physical Science and Technology College, Zhengzhou University, 450001, Zhengzhou, China;Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, 100049, Beijing, China;Beijing Engineering Research Center of Radiographic Techniques and Equipment, 100049, Beijing, China;The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 250001, Jinan, China;

关键词: Amnestic mild cognitive impairment;    Default mode network;    Functional magnetic resonance imaging;    Functional connectivity;    Independent component analysis;   

DOI  :  10.1186/s12880-017-0221-9

 received in 2017-01-21, accepted in 2017-07-31,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAmnestic mild cognitive impairment (aMCI) is characterized by cognitive functional decline, especially in memory. Resting-state functional magnetic resonance imaging (fMRI) has been widely used in neuroimaging studies that explore alterations between patients and normal individuals to elucidate the pathological mechanisms of different diseases. The current study was performed to investigate alterations in the functional connectivity of the default mode network (DMN) in aMCI patients compared to healthy elderly controls, as well as further define the association between neurological alterations and memory function.MethodsTwenty-five aMCI patients and 25 healthy individuals were recruited and underwent both fMRI and neuropsychological examinations. fMRI data was analyzed by independent component analysis.ResultsCompared to healthy individuals, aMCI patients exhibited a significant increase in functional connectivity between the DMN and right-middle and right-superior frontal gyri, left-middle occipital gyrus, and left-middle temporal gyrus, but reduced functional connectivity between the DMN and left-middle and left-inferior frontal gyri and left insula. These alterations were found to be associated with reduced memory function.ConclusionsaMCI patients exhibited abnormal functional connectivity between the DMN and certain brain regions which is associated with changes in memory function associated with aMCI.

【 授权许可】

CC BY   
© The Author(s). 2017