In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract

BMC Complementary and Alternative Medicine

Research Article

Cháriston André Dal Belo¹  Patricia Santos Lopes²  Francisco Carlos Groppo³  Márcio Galdino dos Santos⁴  Thaisa Borim⁵  Natália Mencacci Esteves-Pedro⁵  Virginia Sbrugnera Nazato⁵  Magali Glauzer Silva⁵  Marli Gerenutti⁵  Yoko Oshima-Franco⁵  Cássia Regina Primila Cardoso⁶  Eliana Aparecida Varanda⁶ 

[1] Federal University of Pampa, UNIPAMPA, Zip code: 97300-000, Av. Antonio Trilha, 1847, São Gabriel, RS, Brazil;Federal University of São Paulo, UNIFESP, Zip code: 09972-270, R. Prof. Artur Riedel, 275, Diadema, SP, Brazil;Piracicaba Dental School - State University of Campinas (UNICAMP), Zip code: 13414-903, Av. Limeira 901, Piracicaba, SP, Brazil;Post-Graduation Course in Environmental Sciences, PGCiamb, Federal University of Tocantins, Zip code: 77001-090, UFT, Av. NS 15 ALC NO 14, 109 Norte, Tocantins, Brazil;School of Pharmacy, University of Sorocaba, UNISO, Zip code: 18023-000, Rodovia Raposo Tavares km 92.5, Sorocaba, SP, Brazil;UNESP-São Paulo State University, Faculty of Pharmaceutical Sciences of Araraquara, Department of Biological Sciences, Rodovia Araraquara-Jaú, Km 1, 14801-902, Araraquara, São Paulo, Brazil;

关键词: Herbal Remedy;    Hydroalcoholic Extract;    Humidity Test;    Neurobehavioral Development;    Mutagenic Index;   

DOI  :  10.1186/1472-6882-12-9

 received in 2011-08-12, accepted in 2012-02-03,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDipteryx alata Vogel popularly known as "baru" is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the "naturally occurring plants" as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract.MethodsVegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats.ResultsThe extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group.ConclusionD. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development.

【 授权许可】

Unknown   
© Esteves-Pedro et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.