Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function

BMC Genomics

Research Article

Patricia L Clark¹  Thomas F Clarke¹ 

[1] Department of Chemistry and Biochemistry, University of Notre Dame, 46556, Notre Dame, IN, USA;

关键词: Codon;    Codon Usage;    Synonymous Codon;    Signal Recognition Particle;    Rare Codon;   

DOI  :  10.1186/1471-2164-11-118

 received in 2009-10-02, accepted in 2010-02-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe process of translation can be affected by the use of rare versus common codons within the mRNA transcript.ResultsHere, we show that rare codons are enriched at the 5' and 3' termini of genes from E. coli and other prokaryotes. Genes predicted to be secreted show significant enrichment in 5' rare codon clusters, but not 3' rare codon clusters. Surprisingly, no correlation between 5' mRNA structure and rare codon usage was observed.ConclusionsPotential functional roles for the enrichment of rare codons at terminal positions are explored.

【 授权许可】

CC BY   
© Clarke and Clark; licensee BioMed Central Ltd. 2010