Resilience of a FIT screening programme against screening fatigue: a modelling study

BMC Public Health

Research Article

Jie-Bin Lew¹  Karen Canfell²  Veerle M. H. Coupé³  Marjolein J. E. Greuter³  Johannes Berkhof³  Evelien Dekker⁴ 

[1] Cancer Research Division, Cancer Council NSW, Sydney, NSW, Australia;Prince of Wales Clinical School, Faculty of Medicine, The University of New South Wales, Sydney, NSW, Australia;Cancer Research Division, Cancer Council NSW, Sydney, NSW, Australia;School of Public Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia;Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, MF F-wing, 1007 MB, Amsterdam, The Netherlands;Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands;

关键词: Colorectal cancer;    Screening;    Participation;   

DOI  :  10.1186/s12889-016-3667-8

 received in 2016-03-02, accepted in 2016-06-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundRepeated participation is important in faecal immunochemical testing (FIT) screening for colorectal cancer (CRC). However, a large number of screening invitations over time may lead to screening fatigue and consequently, decreased participation rates. We evaluated the impact of screening fatigue on overall screening programme effectiveness.MethodsUsing the ASCCA model, we simulated the Dutch CRC screening programme consisting of biennial FIT screening in individuals aged 55–75. We studied the resilience of the programme against heterogeneity in screening attendance and decrease in participation rate due to screening fatigue. Outcomes were reductions in CRC incidence and mortality compared to no screening.ResultsAssuming a homogenous 63 % participation, i.e., each round each individual was equally likely to attend screening, 30 years of screening reduced CRC incidence and mortality by 39 and 53 %, respectively, compared to no screening. When assuming clustered participation, i.e., three subgroups of individuals with a high (95 %), moderate (65 %) and low (5 %) participation rate, screening was less effective; reductions were 33 % for CRC incidence and 43 % for CRC mortality. Screening fatigue considerably reduced screening effectiveness; if individuals refrained from screening after three negative screens, model-predicted incidence reductions decreased to 25 and 18 % under homogenous and clustered participation, respectively. Figures were 34 and 25 % for mortality reduction.ConclusionsScreening will substantially decrease CRC incidence and mortality. However, screening effectiveness can be seriously compromised if screening fatigue occurs. This warrants careful monitoring of individual screening behaviour and consideration of targeted invitation systems in individuals who have (repeatedly) missed screening rounds.

【 授权许可】

CC BY   
© The Author(s). 2016