Effect of neuroticism on risk of cardiovascular disease in depressed persons - a Swedish population-based cohort study

BMC Cardiovascular Disorders

Research Article

Romaina Iqbal¹  Jette Moller²  Yvonne Forsell²  Aysha Almas³ 

[1] Department of Medicine, Aga Khan University, Karachi, Pakistan;Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan;Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden;Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden;Department of Medicine, Aga Khan University, Karachi, Pakistan;

关键词: Depression;    Neuroticism;    Cardiovascular diseases;    Cohort study;   

DOI  :  10.1186/s12872-017-0604-4

 received in 2016-11-07, accepted in 2017-06-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe relationship between neuroticism, depression and cardiovascular disease (CVD) is complex and has so far not been studied in depth. The aim of this study was to determine if neuroticism is an effect-modifier in the association between depression and CVD. Data derived from a longitudinal cohort study on mental health, work and relations among adults (20–64 years), including 10,443 individuals. Depression was assessed using the Major Depression Inventory (MDI) and neuroticism by the Swedish Scale of Personality (SSP). Outcomes of cardiovascular disease were register-based from the National inpatient register.ResultsBoth depression (OR 1.9 (95%CI 1.4, 2.5)) and high levels of neuroticism (OR 1.2 (95%CI 1.1–1.3)) were associated with increased risk of CVD. The combined effect of depression and neuroticism on the risk of CVD revealed HRs ranging from 1.0 to 1.9 after adjusting for age and gender, socioeconomic position, prevalent hypertension and diabetes. Almost similar associations were seen after further adjustment for lifestyle factors.ConclusionNeuroticism increased the risk of CVD in depressed persons. We found synergistic interaction between neuroticism and depression status in predicting future risk of CVD.

【 授权许可】

CC BY   
© The Author(s). 2017