The impact of PTSD on risk of cardiometabolic diseases: a national patient cohort study in Norway

BMC Psychiatry

Research

Ingeborg Bolstad¹  Jan O. Aaseth²  Grethe Emilie Roer³  Dawit Shawel Abebe³  Lars Lien⁴ 

[1] Faculty of Social and Health Sciences, Inland Norway University of Applied Sciences, P.O. Box 400, NO-2418, Elverum, Norway;Faculty of Social and Health Sciences, Inland Norway University of Applied Sciences, P.O. Box 400, NO-2418, Elverum, Norway;Research Department, Innlandet Hospital Trust, P.O. Box 104, NO-2381, Brumunddal, Norway;Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, P.O. Box 104, NO-2381, Brumunddal, Norway;Department of Nursing and Health Promotion, Oslo Metropolitan University, P.O. Box 4, St. Olavs Plass, NO-0130, Oslo, Norway;Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, P.O. Box 104, NO-2381, Brumunddal, Norway;Faculty of Social and Health Sciences, Inland Norway University of Applied Sciences, P.O. Box 400, NO-2418, Elverum, Norway;

关键词: Posttraumatic stress disorder;    Alcohol use disorder;    Depression;    Comorbidity;    Cardiovascular diseases;    Metabolic diseases;    Diabetes mellitus;    Epidemiology;    Register data;    Cohort study;   

DOI  :  10.1186/s12888-023-04866-x

 received in 2022-07-06, accepted in 2023-05-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPosttraumatic stress disorder (PTSD) is associated with cardiometabolic diseases, concurrent anxiety, alcohol use disorder and depression. The relationship between PTSD and cardiometabolic diseases are still unclear, and less is known about the effects of socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression. The study, therefore, aims to examine the risk of developing cardiometabolic diseases including type 2 diabetes mellitus over time in PTSD patients, and to what extent socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression attenuate associations between PTSD and risk of developing cardiometabolic diseases.MethodA retrospective, register-based cohort study with 6-years follow-up of adult (> 18 years) PTSD patients (N = 7 852) compared with the general population (N = 4 041 366), was performed. Data were acquired from the Norwegian Patient Registry and Statistic Norway. Cox proportional regression models were applied to estimate hazard ratios (HRs) (99% confidence intervals) of cardiometabolic diseases among PTSD patients.ResultsSignificantly (p < 0.001) higher age and gender adjusted HRs were disclosed for all cardiometabolic diseases among PTSD patients compared to the population without PTSD, with a variation in HR from 3.5 (99% CI 3.1–3.9) for hypertensive diseases to HR = 6.5 (5.7–7.5) for obesity. When adjusted for socioeconomic status and comorbid mental disorders, reductions were observed, especially for comorbid depression, for which the adjustment resulted in HR reduction of about 48.6% for hypertensive diseases and 67.7% for obesity.ConclusionsPTSD was associated with increased risk of developing cardiometabolic diseases, though attenuated by socioeconomic status and comorbid mental disorders. Health care professionals should be attentive towards the burden and increased risk that low socioeconomic status and comorbid mental disorders may represent for PTSD patients’ cardiometabolic health.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1