Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women

BMC Musculoskeletal Disorders

Research Article

Anwarjan Yusup¹  Ryo Sadatsuki²  Haruka Kaneko²  Ippei Futami²  Shinnosuke Hada²  Muneaki Ishijima³  Kazuo Kaneko³  Hisashi Kurosawa⁴  Yuji Takazawa⁵  Yoshitomo Saita⁵  Takayuki Kawasaki⁵  Hiroshi Ikeda⁵  Mitsuaki Kubota⁵  Lizu Liu⁶  Tokuhide Doi⁷ 

[1] Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Orthopaedics, Faculty of Medicine, Juntendo University, Tokyo, Japan;Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Orthopaedics, Faculty of Medicine, Juntendo University, Tokyo, Japan;Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Orthopaedic Surgery, Juntendo Tokyo Metropolitan Koto Geriatric Medical Center, Tokyo, Japan;Department of Orthopaedics, Faculty of Medicine, Juntendo University, Tokyo, Japan;Department of Orthopaedics, Faculty of Medicine, Juntendo University, Tokyo, Japan;Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan;Fukuoka Clinic, Tokyo, Japan;

关键词: Osteoarthritis (OA);    Hyarulonic Acid (HA);    Reference intervals;    Biomarker;    Radiography;   

DOI  :  10.1186/1471-2474-14-34

 received in 2012-04-27, accepted in 2013-01-15,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroudWhile serum levels of hyarulonic acid (sHA) is known to be useful for a burden of disease biomarker in knee OA, it is far from practical. The reference intervals must be established for biomarkers to be useful for clinical interpretation. The aim of this study was to establish the reference intervals of sHA corresponding to the radiographic severity of knee OA for elucidating whether sHA can be useful as a burden of disease marker for individual patient with knee OA.Methods372 women with Kellgren & Lawrence grade (K/L) 1 through 4 painful knee OA were enrolled in this study. The patients included 54 with K/L 1, 96 with K/L 2, 97 with K/L 3, and 118 with K/L 4. Serum samples were obtained from all subjects on the day that radiographs taken. A HA binding protein based latex agglutination assay that employed an ELISA format was used to measure sHA. Age and BMI adjusted one way ANOVA was used to set the reference intervals of sHA.ResultsThe reference intervals for sHA corresponding to the patients with K/L 4 (49.6 – 66.5 ng/ml) was established without any overlap against to those with K/L 1, 2 and 3, while those with K/L 1, 2 and 3 showed considerable overlap.ConclusionsThese results indicate that sHA can be available as a burden of disease marker for the individuals with severe knee OA (K/L 4), while it is not for those with primary to moderate knee OA (K/L 1–3).

【 授权许可】

Unknown   
© Kaneko et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.