Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women

BMC Musculoskeletal Disorders

Kazuo Kaneko⁵  Hisashi Kurosawa¹  Hiroshi Ikeda³  Yuji Takazawa³  Yoshitomo Saita³  Takayuki Kawasaki³  Mitsuaki Kubota³  Shinnosuke Hada³  Anwarjan Yusup²  Ryo Sadatsuki³  Lizu Liu⁵  Ippei Futami³  Tokuhide Doi⁴  Muneaki Ishijima⁵  Haruka Kaneko³ 

[1] Department of Orthopaedic Surgery, Juntendo Tokyo Metropolitan Koto Geriatric Medical Center, Tokyo, Japan;Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Orthopaedics, Faculty of Medicine, Juntendo University, Tokyo, Japan;Fukuoka Clinic, Tokyo, Japan;Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

关键词: Radiography;    Biomarker;    Reference intervals;    Hyarulonic Acid (HA);    Osteoarthritis (OA);   

Others  :  1134156
DOI  :  10.1186/1471-2474-14-34

 received in 2012-04-27, accepted in 2013-01-15,  发布年份 2013

【 摘 要 】

Backgroud

While serum levels of hyarulonic acid (sHA) is known to be useful for a burden of disease biomarker in knee OA, it is far from practical. The reference intervals must be established for biomarkers to be useful for clinical interpretation. The aim of this study was to establish the reference intervals of sHA corresponding to the radiographic severity of knee OA for elucidating whether sHA can be useful as a burden of disease marker for individual patient with knee OA.

Methods

372 women with Kellgren & Lawrence grade (K/L) 1 through 4 painful knee OA were enrolled in this study. The patients included 54 with K/L 1, 96 with K/L 2, 97 with K/L 3, and 118 with K/L 4. Serum samples were obtained from all subjects on the day that radiographs taken. A HA binding protein based latex agglutination assay that employed an ELISA format was used to measure sHA. Age and BMI adjusted one way ANOVA was used to set the reference intervals of sHA.

Results

The reference intervals for sHA corresponding to the patients with K/L 4 (49.6 – 66.5 ng/ml) was established without any overlap against to those with K/L 1, 2 and 3, while those with K/L 1, 2 and 3 showed considerable overlap.

Conclusions

These results indicate that sHA can be available as a burden of disease marker for the individuals with severe knee OA (K/L 4), while it is not for those with primary to moderate knee OA (K/L 1–3).

【 授权许可】

   
2013 Kaneko et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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