Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment

BMC Cancer

Research Article

Lothar Haeberle¹  Alexander Hein¹  Laura Kahmann¹  Claudia Rauh¹  Christian M Bayer¹  Michael P Lux¹  Mayada R Bani¹  Matthias W Beckmann¹  Michael Schrauder¹  Melitta Niklos¹  Katharina Heusinger¹  Peter A Fasching²  Ruediger Schulz-Wendtland³  Johanna D Strehl⁴  David L Wachter⁴  Arndt Hartmann⁴  Arno Dimmler⁵ 

[1] Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany;Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, California, USA;Institute of Diagnostic Radiology, Erlangen University Hospital, Erlangen, Germany;Institute of Pathology, Erlangen University Hospital, Erlangen, Germany;Institute of Pathology, St Vincentius Hospital, Karlsruhe, Germany;

关键词: Overall Survival;    Trastuzumab;    Molecular Subtype;    HER2 Status;    Molecular Subgroup;   

DOI  :  10.1186/1471-2407-11-486

 received in 2011-03-03, accepted in 2011-11-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of predicting a pCR, such as the proliferation marker Ki67, may therefore help improve our understanding of the drug response and its effect on the prognosis. This study investigated the predictive and prognostic value of Ki67 in patients with invasive breast cancer receiving neoadjuvant treatment for breast cancer.MethodsKi67 was stained routinely from core biopsies in 552 patients directly after the fixation and embedding process. HER2/neu, estrogen and progesterone receptors, and grading were also assessed before treatment. These data were used to construct univariate and multivariate models for predicting pCR and prognosis. The tumors were also classified by molecular phenotype to identify subgroups in which predicting pCR and prognosis with Ki67 might be feasible.ResultsUsing a cut-off value of > 13% positively stained cancer cells, Ki67 was found to be an independent predictor for pCR (OR 3.5; 95% CI, 1.4, 10.1) and for overall survival (HR 8.1; 95% CI, 3.3 to 20.4) and distant disease-free survival (HR 3.2; 95% CI, 1.8 to 5.9). The mean Ki67 value was 50.6 ± 23.4% in patients with pCR. Patients without a pCR had an average of 26.7 ± 22.9% positively stained cancer cells.ConclusionsKi67 has predictive and prognostic value and is a feasible marker for clinical practice. It independently improved the prediction of treatment response and prognosis in a group of breast cancer patients receiving neoadjuvant treatment. As mean Ki67 values in patients with a pCR were very high, cut-off values in a high range above which the prognosis may be better than in patients with lower Ki67 values may be hypothesized. Larger studies will be needed in order to investigate these findings further.

【 授权许可】

CC BY   
© Fasching et al; licensee BioMed Central Ltd. 2011