期刊论文详细信息
BMC Pulmonary Medicine
Effect of obesity on constant workrate exercise in hyperinflated men with COPD
Research Article
Alan L Hamilton1  Steven Kesten2  Francesco Sava3  Louis Laviolette3  François Maltais3  Denis E O'Donnell4  Katherine A Webb4 
[1] Boehringer Ingelheim (Canada) Limited, Ontario, Burlington, Canada;Boehringer Ingelheim Corporation, Ingelheim, Germany;Centre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada;Respiratory Investigation Unit, Department of Medicine, Queen's University, Ontario, Kingston, Canada;
关键词: Body Mass Index;    Chronic Obstructive Pulmonary Disease;    Lung Volume;    Normal Body Mass Index;    Tiotropium;   
DOI  :  10.1186/1471-2466-10-33
 received in 2010-02-05, accepted in 2010-05-30,  发布年份 2010
来源: Springer
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【 摘 要 】

BackgroundChronic obstructive pulmonary disease (COPD) and a high body mass index (BMI) can both affect pulmonary volumes as well as exercise tolerance, but their combined effect on these outcomes is not well known. The aim of this study was to investigate the effects of increased BMI during constant workrate cycle ergometry in patients with COPD.MethodsMen with COPD and hyperinflation were divided according to World Health Organization BMI classification: 84 normal BMI (NBMI), 130 overweight (OW) and 64 obese (OB). Patients underwent spirometric and lung volumes assessment and an incremental cycling exercise test. This was followed by a constant workrate exercise test (CET) at 75% of peak capacity. Inspiratory capacity and Borg dyspnea scores were measured at baseline, during and at the end of CET.Results and discussionFEV1 % predicted was not different across BMI classes. Total lung capacity and functional residual capacity were significantly lower in OB and OW compared to NBMI patients. Peak VO2 in L·min-1 was significantly higher in OB and OW patients than in NBMI patients. CET time was not different across BMI classes (p = 0.11). Changes in lung volumes and dyspnea during CET were not different between BMI categories.ConclusionsOB and OW patients with COPD had a higher peak VO2 than their lean counterparts. Endurance time, dyspnea and changes in lung volumes during CET were similar between BMI categories.

【 授权许可】

Unknown   
© Laviolette et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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