Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study

BMC Urology

Research Article

Mario Maggi¹  Linda Vignozzi¹  Giorgio Ivan Russo²  Giuseppe Morgia²  Cosimo De Nunzio³  Andrea Tubaro³  Arcangelo Sebastianelli⁴  Marco Carini⁴  Sergio Serni⁴  Matteo Salvi⁴  Tommaso Jaeger⁴  Tommaso Chini⁴  Mauro Gacci⁴  Giovanni Corona⁵ 

[1] Department of Clinical Physiopathology, University of Florence, Florence, Italy;Department of Urology, Policlinico Hospital, University of Catania, Catania, Italy;Department of Urology, Sant’Andrea Hospital, University “La Sapienza”, Rome, Italy;Department of Urology, University of Florence, Careggi Hospital, Florence, Italy;Endocrinology Unit, Maggiore-Bellaria Hospital, Bologna, Italy;

关键词: Benign prostatic enlargement;    Benign prostatic hyperplasia;    Lower urinary tract symptoms;    Metabolic syndrome;    Dyslipidemia;   

DOI  :  10.1186/s12894-017-0211-9

 received in 2016-02-18, accepted in 2017-03-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIn last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in men surgically treated for BPE.MethodsOverall, 379 men were prospectively enrolled in two tertiary referral centers. Calculated prostate volume (PV) was measured with transrectal US defining the antero-posterior (AP), the cranio-caudal (CC) and the latero-lateral (LL) diameters through the ellipsoid formula, while raw PV was calculated by suprapubic US. MetS was defined according to the NCEP-ATPIII criteria.ResultsOne-hundred and forty men (36.9%) were affected by MetS. The number of MetS parameters (0 to 5) and the presence of MetS were correlated with the calculated PV. The number of MetS parameters were also directly related to increasing prostate diameters. At the binary logistic regression, MetS resulted associated to high (>60 cc) raw and calculated PV. Moreover, multivariate analysis suggested that AP diameter was mainly correlated with HDL cholesterol (r:-0.3103, p = 0.002) CC diameter with triglycerides (r:-0.191, p = 0.050) and LL diameter with systolic blood pressure (r:0.154, p = 0.044). However, at the binary logistic regression, only low HDL Cholesterol was the main determinant for the enlargement of all diameters and consequently of the whole PV.ConclusionsMetabolic factors, specially dyslipidemia, could play a central role in the pathogenesis and progression of BPE/LUTS. Interventional studies are needed to evaluate the impact of early treatment of dyslipidemia on progression of LUTS/BPH.

【 授权许可】

CC BY   
© The Author(s). 2017