Endosialin expression in relation to clinicopathological and biological variables in rectal cancers with a Swedish clinical trial of preoperative radiotherapy

BMC Cancer

Research Article

Xiao-Feng Sun¹  Zhi-Yong Zhang²  Gunnar Adell³  Hong Zhang⁴ 

[1] Department of Oncology, Institute of Clinical and Experimental Medicine, Linköping University, S-581 85, Linköping, Sweden;Department of Oncology, Institute of Clinical and Experimental Medicine, Linköping University, S-581 85, Linköping, Sweden;Department of Pathology, Tangshan Gongren Hospital, Tangshan, P.R. China;Laboratory Centre, First Hospital of Hebei Medical University, Shijiazhuang, P.R. China;Department of Oncology, Karolinska University Hospital, Stockholm, Sweden;Division of Biomedicine, School of Life Science, University of Skövde, Skövde, Sweden;

关键词: Rectal Cancer;    Normal Mucosa;    Rectal Cancer Patient;    Adjacent Normal Mucosa;    Infiltrative Growth Pattern;   

DOI  :  10.1186/1471-2407-11-89

 received in 2009-10-29, accepted in 2011-03-01,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe importance of changes in tumour-associated stroma for tumour initiation and progression has been established. Endosialin is expressed in fibroblasts and pericytes of blood vessels in several types of tumours, and is involved in the progression of colorectal cancer. In order to see whether endosialin was related to radiotherapy (RT) response, and clinicopathological and biological variables, we investigated endosialin expression in rectal cancers from the patients who participated in a Swedish clinical trial of preoperative RT.MethodsEndosialin was immunohistochemically examined in normal mucosa, including distant (n = 72) and adjacent (n = 112) normal mucosa, and primary tumours (n = 135). Seventy-three of 135 patients received surgery alone and 62 received additional preoperative RT.ResultsEndosialin expression in the stroma increased from normal mucosa to tumour (p < 0.0001) both in RT and non-RT group. In the RT group, endosialin expression in the stroma was positively associated with expression of cyclooxygenase-2 (Cox-2) (p = 0.03), p73 (p = 0.01) and phosphates of regenerating liver (PRL) (p = 0.002). Endosialin expression in the tumour cells of both in the RT group (p = 0.01) and the non-RT group (p = 0.06) was observed more often in tumours with an infiltrative growth pattern than in tumours with an expansive growth pattern. In the RT group, endosialin expression in tumour cells was positively related to PRL expression (p = 0.02), whereas in the non-RT group, endosialin expression in tumour cells was positively related to p73 expression (p = 0.01).ConclusionsEndosialin expression may be involved in the progression of rectal cancers, and was related to Cox-2, p73 and PRL expression. However, a direct relationship between endosialin expression and RT responses in patients was not found.

【 授权许可】

Unknown   
© Zhang et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.