Comparison of Acoustic Structure Quantification (ASQ), shearwave elastography and histology in patients with diffuse hepatopathies

BMC Medical Imaging

Research Article

Tilmann Graeter¹  Tanja Eva-Maria Kaltenbach²  Thomas Seufferlein²  Suemeyra Oeztuerk²  Jan Keller²  Mark Martin Haenle²  Wolfgang Kratzer³  Richard Andrew Mason⁴ 

[1] Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany;Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany;Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany;Universitätsklinikum Ulm, Zentrum für Innere Medizin, Klinik für Innere Medizin I, Albert-Einstein-Allee 23, D-89081, Ulm, Germany;Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10601 East Boulevard, 44106, Cleveland, OH, USA;

关键词: Acoustic Structure Quantification (ASQ);    Acoustic Radiation Force Impulse (ARFI);    Elastography;    Liver fibrosis;    Virtual touch;   

DOI  :  10.1186/s12880-015-0100-1

 received in 2015-07-02, accepted in 2015-11-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundObjective of the study was to evaluate the diagnostic value of novel ultrasonographic modalities in comparison with simultaneously performed liver biopsy.MethodsThe results of simultaneously performed examinations using Acoustic Structure Quantification (ASQ), Virtual Touch Imaging and Quantification (VTIQ) and Virtual Touch Tissue Quantification (VTTQ) were compared with the findings of liver biopsy in patients with a wide variety of diffuse hepatopathies (n = 51). The histologically determined fibrosis stage according to Desmet and Scheuer was compared with quantitative measurements returned by the ultrasonographic imaging modalities.ResultsNo statistically significant correlation with histologically determined fibrosis stage could be identified for any measurements returned using ASQ. Increasing severity of hepatic steatosis, however, was associated with a reduction in the focal disturbance (FD) ratio (r = −0.55; p < 0.0001). The shearwave velocities measured using VTTQ satisfyingly correlated with fibrosis stage (r = 0.56; p > 0.0001). Fibrosis stages > F2 were associated with an area under the curve (AUC) of 0.94 (95 %-CI:0.84–0.99). A cut-off value for shearwave velocity of 1.66 m/s was determined with a sensitivity of 100 % and a specificity of 84 %. VTIQ showed a less pronounced but acceptable correlation with fibrosis stage (r = 0.35; p = 0.0154). For fibrosis stages > F2 analysis showed an AUC of 0.84 (95 %-CI:0.70–0.93). The cut-off value was 1.82 m/s with a sensitivity of 100 % and a specificity of 58 %.ConclusionWhile ASQ showed no diagnostic advantage in our patient collective, VTTQ showed high reliability for determining severe liver fibrosis in a group of patients with diffuse liver diseases of different etiology.

【 授权许可】

CC BY   
© Keller et al. 2015