Association between serum and dietary antioxidant micronutrients and advanced liver fibrosis in non-alcoholic fatty liver disease: an observational study

PeerJ

article

Juliana Moraes Coelho¹  Katia Cansanção²  Renata de Mello Perez³  Nathalie Carvalho Leite⁴  Patrícia Padilha²  Andrea Ramalho⁵  Wilza Peres² 

[1] The Capriglione Luiz State Institute of Diabetes and Endocrinology;Universidade Federal do Rio de Janeiro;Universidade Federal do Rio de Janeiro and D’Or Institute for Research and Education;Department of Internal Medicine, Universidade Federal do Rio de Janeiro;Department of Social and Applied Nutrition and Center for Research on Micronutrients ,(NPqM), Universidade Federal do Rio de Janeiro

关键词: NAFLD;    Liver fibrosis;    Elastography;    Antioxidants;    Micronutrients;    Retinol;    Vitamin C;    Vitamin E;    Selenium;    Zinc;   

DOI  :  10.7717/peerj.9838

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Despite clinical trials with antioxidant supplementation, few studies have been conducted to evaluate the nutritional status of antioxidant vitamins and minerals, and none have reported on the status of these serum antioxidants associated with the dietary intake of antioxidants by non-alcoholic fatty liver disease (NAFLD) patients. Objective To evaluate association between serum and dietetics antioxidants with liver fibrosis in patients with NAFLD. Methods Across-section analysis with out with 72 patients diagnosed with NAFLD. Hepatic fibrosis was measured by FibroScan®, and liver stiffness ≥7.9 kPa was considered to indicate advanced fibrosis. Retinol, alpha-tocopherol, ascorbic acid, beta-carotene, serum zinc, and selenium were evaluated, as was the dietary intake of these micronutrients in the previous 24 h (using 24-h dietary recall). The Mann–Whitney test was used to compare the fibrosis groups and, a linear regression analysis was performed to determine associated risk factors between age, sex, BMI, hepatic fibrosis, and serum antioxidants. Results A high proportion of inadequate serum retinol (20.8%), vitamin C (27%), and selenium (73.6%) was observed in the patients with NAFLD, in addition to a significant inadequacy of vitamin A (98.3%) and vitamin E (100%) intake. Patients with advanced liver fibrosis had reduced levels of serum retinol (P = 0.002), with liver fibrosis being the independent risk factor associated with serum retinol lower. Conclusion Hepatic fibrosis was associated with a reduction in serum retinol and was reduced in advanced fibrosis. NAFLD patients showed an important serum deficiency and insufficient dietary intake of the evaluated micronutrients.

【 授权许可】

CC BY