Gastro oesophageal reflux disease (GORD)-related symptoms and its association with mood and anxiety disorders and psychological symptomology: a population-based study in women

BMC Psychiatry

Research Article

Amanda L Stuart¹  Lana J Williams²  Michael Berk³  Julie A Pasco⁴  Paolo Girardi⁵  Livia Sanna⁶ 

[1] IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, 3220, Geelong, Australia;IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, 3220, Geelong, Australia;Department of Psychiatry, The University of Melbourne, Parkville, Australia;IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, 3220, Geelong, Australia;Department of Psychiatry, The University of Melbourne, Parkville, Australia;Orygen Youth Health Research Centre, Parkville, Australia;IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, 3220, Geelong, Australia;Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia;NorthWest Academic Centre, Department of Medicine, The University of Melbourne, Western Health, St Albans, Australia;Department of Medicine, Barwon Health, Geelong, Australia;Unit of Psychiatry, Neurosciences, Mental Health and Sensory Organs Department (NeSMOS), Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy;Unit of Psychiatry, Neurosciences, Mental Health and Sensory Organs Department (NeSMOS), Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy;IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, 3220, Geelong, Australia;

关键词: Mood disorder;    Anxiety disorder;    Gastro-oesophageal reflux disease (GORD);    Psychological symptoms;    Comorbidity;    Depression;    Gastrointestinal tract;    Somatic;    Comorbidity;   

DOI  :  10.1186/1471-244X-13-194

 received in 2013-06-03, accepted in 2013-06-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPsychopathology seems to play a role in reflux pathogenesis and vice versa, yet few population-based studies have systematically investigated the association between gastro-oesophageal reflux disease (GORD) and psychopathology. We thus aimed to investigate the relationship between GORD-related symptoms and psychological symptomatology, as well as clinically diagnosed mood and anxiety disorders in a randomly selected, population-based sample of adult women.MethodsThis study examined data collected from 1084 women aged 20-93 yr participating in the Geelong Osteoporosis Study. Mood and anxiety disorders were identified using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP), and psychological symptomatology was assessed using the General Health Questionnaire (GHQ-12). GORD-related symptoms were self-reported and confirmed by medication use where possible and lifestyle factors were documented.ResultsCurrent psychological symptomatology and mood disorder were associated with increased odds of concurrent GORD-related symptoms (adjusted OR 2.1, 95% CI 1.3-3.5, and OR 3.0, 95% CI 1.7-5.6, respectively). Current anxiety disorder also tended to be associated with increased odds of current GORD-related symptoms (p = 0.1). Lifetime mood disorder was associated with a 1.6-fold increased odds of lifetime GORD-related symptoms (adjusted OR 1.6, 95% CI 1.1-2.4) and lifetime anxiety disorder was associated with a 4-fold increased odds of lifetime GORD-related symptoms in obese but not non-obese participants (obese, age-adjusted OR 4.0, 95% CI 1.8-9.0).ConclusionsThese results indicate that psychological symptomatology, mood and anxiety disorders are positively associated with GORD-related symptoms. Acknowledging this common comorbidity may facilitate recognition and treatment, and opens new questions as to the pathways and mechanisms of the association.

【 授权许可】

Unknown   
© Sanna et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.