Gastro oesophageal reflux disease (GORD)-related symptoms and its association with mood and anxiety disorders and psychological symptomology: a population-based study in women

BMC Psychiatry

Lana J Williams¹  Paolo Girardi⁵  Julie A Pasco³  Michael Berk⁴  Amanda L Stuart²  Livia Sanna² 

[1] Department of Psychiatry, The University of Melbourne, Parkville, Australia;IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 281, Geelong 3220, Australia;Department of Medicine, Barwon Health, Geelong, Australia;Orygen Youth Health Research Centre, Parkville, Australia;Unit of Psychiatry, Neurosciences, Mental Health and Sensory Organs Department (NeSMOS), Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

关键词: Comorbidity;    Somatic;    Gastrointestinal tract;    Depression;    Comorbidity;    Psychological symptoms;    Gastro-oesophageal reflux disease (GORD);    Anxiety disorder;    Mood disorder;   

Others  :  1123999
DOI  :  10.1186/1471-244X-13-194

 received in 2013-06-03, accepted in 2013-06-05,  发布年份 2013

【 摘 要 】

Background

Psychopathology seems to play a role in reflux pathogenesis and vice versa, yet few population-based studies have systematically investigated the association between gastro-oesophageal reflux disease (GORD) and psychopathology. We thus aimed to investigate the relationship between GORD-related symptoms and psychological symptomatology, as well as clinically diagnosed mood and anxiety disorders in a randomly selected, population-based sample of adult women.

Methods

This study examined data collected from 1084 women aged 20-93 yr participating in the Geelong Osteoporosis Study. Mood and anxiety disorders were identified using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP), and psychological symptomatology was assessed using the General Health Questionnaire (GHQ-12). GORD-related symptoms were self-reported and confirmed by medication use where possible and lifestyle factors were documented.

Results

Current psychological symptomatology and mood disorder were associated with increased odds of concurrent GORD-related symptoms (adjusted OR 2.1, 95% CI 1.3-3.5, and OR 3.0, 95% CI 1.7-5.6, respectively). Current anxiety disorder also tended to be associated with increased odds of current GORD-related symptoms (p = 0.1). Lifetime mood disorder was associated with a 1.6-fold increased odds of lifetime GORD-related symptoms (adjusted OR 1.6, 95% CI 1.1-2.4) and lifetime anxiety disorder was associated with a 4-fold increased odds of lifetime GORD-related symptoms in obese but not non-obese participants (obese, age-adjusted OR 4.0, 95% CI 1.8-9.0).

Conclusions

These results indicate that psychological symptomatology, mood and anxiety disorders are positively associated with GORD-related symptoms. Acknowledging this common comorbidity may facilitate recognition and treatment, and opens new questions as to the pathways and mechanisms of the association.

【 授权许可】

   
2013 Sanna et al.; licensee BioMed Central Ltd.

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